2-羟基-4,6-二甲氧基苯甲酸合成路线 （共 25 条）
反应条件
sodium methylate in methanol T=120°C; Kolbe-Schmitt reaction; P=30400 Torr; 12 h;
参考文献
Fuerstner, Alois; Seidel, Guenter; Kindler, Nicole
Tetrahedron, 1999 , vol. 55, # 27 p. 8215 - 8230
反应条件
1: 3-bromo-3,5-dimethoxyphenol With n-butyllithium in tetrahydrofuran; hexane T=-25°C; 2 h; 2: carbon dioxide in tetrahydrofuran; dichloromethane T=20°C; Further stages.;
参考文献
Runge; Haufe
Journal of Organic Chemistry, 2000 , vol. 65, # 25 p. 8737 - 8742
反应条件
2,3-dihydroxybenzoate decarboxylase from Aspergillus oryzae in aq. phosphate buffer T=30°C; Kolbe-Schmidt Synthesis; 24 h; Enzymatic reaction; regioselective reaction;
参考文献
RSC Advances, , vol. 4, # 19 p. 9673 - 9679
反应条件
1.1: 97 percent / 3 h / 110 °C 2.1: 90 percent / NBS / CH2Cl2 / 1 h / 0 °C 3.1: 67 percent / KOH / methanol / 2.5 h / 20 °C 4.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -25 °C 4.2: 65 percent / tetrahydrofuran; CH2Cl2 / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 25 p. 8737 - 8742
反应条件
1.1: 90 percent / NBS / CH2Cl2 / 1 h / 0 °C 2.1: 67 percent / KOH / methanol / 2.5 h / 20 °C 3.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -25 °C 3.2: 65 percent / tetrahydrofuran; CH2Cl2 / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 25 p. 8737 - 8742
反应条件
1.1: 67 percent / KOH / methanol / 2.5 h / 20 °C 2.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -25 °C 2.2: 65 percent / tetrahydrofuran; CH2Cl2 / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 25 p. 8737 - 8742
反应条件
sulfuric acid T=80°C;
参考文献
Monatshefte fuer Chemie, , vol. 23, p. 95
反应条件
1: H2SO4 / ethanol 2: H2SO4 / acetic acid View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 1 p. 416 - 419
反应条件
toluene-4-sulfonic acid in benzene 0.0166667 h; Heating;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2856 - 2865
反应条件
ruthenium(IV) oxide; sodium periodate 1) 5 h, room temp., pyridine; 2) acetic ester, water, 20 min : decomposition reaction;
参考文献
Liebigs Annalen der Chemie, , # 2 p. 401 - 406
