3,6-二氢-2H-吡喃合成路线 （共 22 条）
反应条件
1: With methanesulfonyl chloride; triethylamine in dichloromethane T=0 - 20°C; 13 h; Inert atmosphere; 2: With 1,8-diazabicyclo[5.4.0]undec-7-ene T=100°C; 3 h;
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
Location in patent: Paragraph 00281 ;
反应条件
sodium hydroxide in water T=90°C; 18 h;
参考文献
ELI LILLY AND COMPANY; JADHAV, Prabhakar Kondaji; SAEED, Ashraf; GREEN, Jonathan Edward; KRISHNAN, Venkatesh; MATTHEWS, Donald Paul; STEPHENSON, Gregory Alan
Patent: WO2013/55577 A1, 2013 ;
Location in patent: Page/Page column 36 ;
反应条件
1: With triethylamine in dichloromethane T=0 - 20°C; 3 h; 2: With 1,8-diazabicyclo[5.4.0]undec-7-ene T=50 - 100°C; 2 h;
参考文献
XI, Ning; WANG, Tingjin; YI, Lei
Patent: WO2013/138210 A1, 2013 ;
Location in patent: Paragraph 0238 ;
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene T=20 - 130°C;
参考文献
Suto; Stier; Werbel; Arundel-Suto; Leopold; Elliott; Sebolt-Leopold
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2484 - 2488
反应条件
Cl2Ni(1,2-bis(diphenylphosphino)ethane) in tetrahydrofuran T=40 - 80°C; 2.5 h; Yield given. Yields of byproduct given;
参考文献
Guagnano, Vito; Lardicci, Luciano; Malanga, Corrado; Menicagli, Rita
Tetrahedron Letters, 1998 , vol. 39, # 14 p. 2025 - 2026
反应条件
Cl2Ni(1,2-bis(diphenylphosphino)ethane) in tetrahydrofuran T=40 - 80°C; 2.5 h; Yield given. Yields of byproduct given;
参考文献
Guagnano, Vito; Lardicci, Luciano; Malanga, Corrado; Menicagli, Rita
Tetrahedron Letters, 1998 , vol. 39, # 14 p. 2025 - 2026
反应条件
methanol; 9-borabicyclo[3.3.1]nonane dimer Yield given. Multistep reaction;
参考文献
Singaram, Bakthan; Rangaishenvi, Milind V.; Brown, Herbert C.; Goralski, Christian G.; Hasha, Dennis L.
Journal of Organic Chemistry, 1991 , vol. 56, # 4 p. 1543 - 1549
反应条件
potassium hydroxide; ethylene glycol
参考文献
Colonge; Boisde
Bulletin de la Societe Chimique de France, 1956 , p. 824
反应条件
toluene-4-sulfonic acid
参考文献
Olsen
Acta Chemica Scandinavica (1947-1973), 1951 , vol. 5, p. 1168,1170
参考文献
Olsen et al.
Acta Chemica Scandinavica (1947-1973), 1952 , vol. 6, p. 859,864
Acta Chemica Scandinavica (1947-1973), 1952 , vol. 6, p. 641,643
