4,5-二甲基-1,2-苯二胺合成路线 （共 140 条）
反应条件
1: With hydrogenchloride; tin(ll) chloride in ethanol; water T=20°C; 1 h; Inert atmosphereReflux; 2: With sodium hydrogencarbonate in ethanol; water T=20°C;
参考文献
UNIVERSITE DE LA MEDITERRANEE AIX-MARSEILLE II; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; CAMPLO, Michel; SIRI, Olivier; SEILLAN, Claire; IOVANNA, Juan; ANDRIEU, Claudia; MORIS, Marc Antoine; ROCCHI, Palma
Patent: WO2011/117830 A1, 2011 ;
Location in patent: Page/Page column 20 ;
反应条件
magnesium in methanol T=45 - 60°C; 1.83333 h;
参考文献
Fan, Xuesen; Zhang, Xinying; Zhang, Yongmin
Journal of Chemical Research, 2005 , # 1 p. 21 - 22
反应条件
palladium monocarbide in ethanol
参考文献
State of Oregon, acting by and through the Oregon State Board of Higher Education, acting for and on behalf of the Oregon Health Sciences University and the University of Oregon, Eugene Oregon; Acea Pharmaceuticals, Inc.; The Regents of the University of California
Patent: US5631373 A1, 1997 ;
反应条件
palladium on activated charcoal; ethanol Hydrogenation;
参考文献
Journal of the American Chemical Society, , vol. 80, p. 1662
反应条件
platinum Hydrogenation;
参考文献
Journal of the American Chemical Society, , vol. 67, p. 2165,2167
反应条件
1: 97.4 percent / conc. HCl / 100 °C 2: 40 g / hydrogene / 2percent Pd/C / aq. ethanol / 2 h / 30 - 60 °C / 44133.5 Torr View Scheme
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 51, # 1 p. 134 - 146,119 - 128
反应条件
1: HNO3, H2SO4 / 5 - 10 °C 2: 97.4 percent / conc. HCl / 100 °C 3: 40 g / hydrogene / 2percent Pd/C / aq. ethanol / 2 h / 30 - 60 °C / 44133.5 Torr View Scheme
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 51, # 1 p. 134 - 146,119 - 128
反应条件
1: 120 °C 2: HNO3, H2SO4 / 5 - 10 °C 3: 97.4 percent / conc. HCl / 100 °C 4: 40 g / hydrogene / 2percent Pd/C / aq. ethanol / 2 h / 30 - 60 °C / 44133.5 Torr View Scheme
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 51, # 1 p. 134 - 146,119 - 128
反应条件
sulfuric acid T=150°C;
参考文献
Archives of Biochemistry, , vol. 29, p. 75,76 Anm.1
反应条件
1: 2 N aq. Na2CO3 / CH2Cl2 / 0 - 5 °C 2: aq. HNO3 / CH2Cl2 / 0.17 h / Ambient temperature View Scheme
参考文献
Argyropoulos, N. G.; Gallos, J. K.; Nicolaides, D. N.
Tetrahedron, 1986 , vol. 42, # 13 p. 3631 - 3636
