1-环己基-3-[4-(1-羟基乙基)苯基]磺酰基脲合成路线 （共 7 条）
反应条件
methanol; potassium carbonate 12 h; Ambient temperature;
参考文献
Akita, Hiroyuki; Kurashima, Katsumi; Nozawa, Masako; Yamamura, Shigeo; Seri, Kenzi; Imamura, Yorishige
Tetrahedron Asymmetry, 1998 , vol. 9, # 24 p. 4331 - 4340
反应条件
1: aq. NH3 / 0.5 h / 40 °C 2: CrO3, aq. AcOH / 3 h / Ambient temperature 3: 95 percent / NaBH4 / methanol / 0.5 h / 0 °C 4: 87 percent / pyridine / 2 h / -10 °C 5: 1.) 1,8-diazabicyclo<5.4.0>undec-7-ene / 1.) benzene, RT, 30 min, 2.) benzene, RT, 1 h 6: 90 percent / K2CO3, MeOH / 12 h / Ambient temperature View Scheme
参考文献
Akita, Hiroyuki; Kurashima, Katsumi; Nozawa, Masako; Yamamura, Shigeo; Seri, Kenzi; Imamura, Yorishige
Tetrahedron Asymmetry, 1998 , vol. 9, # 24 p. 4331 - 4340
反应条件
1: 95 percent / NaBH4 / methanol / 0.5 h / 0 °C 2: 87 percent / pyridine / 2 h / -10 °C 3: 1.) 1,8-diazabicyclo<5.4.0>undec-7-ene / 1.) benzene, RT, 30 min, 2.) benzene, RT, 1 h 4: 90 percent / K2CO3, MeOH / 12 h / Ambient temperature View Scheme
参考文献
Akita, Hiroyuki; Kurashima, Katsumi; Nozawa, Masako; Yamamura, Shigeo; Seri, Kenzi; Imamura, Yorishige
Tetrahedron Asymmetry, 1998 , vol. 9, # 24 p. 4331 - 4340
反应条件
1: CrO3, aq. AcOH / 3 h / Ambient temperature 2: 95 percent / NaBH4 / methanol / 0.5 h / 0 °C 3: 87 percent / pyridine / 2 h / -10 °C 4: 1.) 1,8-diazabicyclo<5.4.0>undec-7-ene / 1.) benzene, RT, 30 min, 2.) benzene, RT, 1 h 5: 90 percent / K2CO3, MeOH / 12 h / Ambient temperature View Scheme
参考文献
Akita, Hiroyuki; Kurashima, Katsumi; Nozawa, Masako; Yamamura, Shigeo; Seri, Kenzi; Imamura, Yorishige
Tetrahedron Asymmetry, 1998 , vol. 9, # 24 p. 4331 - 4340
反应条件
in vitro reduction in the presence of NADPH or NADH; effects of various inhibitors on reducing activity;
参考文献
Ohara, Hirotami; Miyabe, Yoshiyuki; Deyashiki, Yoshihiro; Matsuura, Kazuya; Hara, Akira
Biochemical Pharmacology, 1995 , vol. 50, # 2 p. 221 - 227
反应条件
1: 87 percent / pyridine / 2 h / -10 °C 2: 1.) 1,8-diazabicyclo<5.4.0>undec-7-ene / 1.) benzene, RT, 30 min, 2.) benzene, RT, 1 h 3: 90 percent / K2CO3, MeOH / 12 h / Ambient temperature View Scheme
参考文献
Akita, Hiroyuki; Kurashima, Katsumi; Nozawa, Masako; Yamamura, Shigeo; Seri, Kenzi; Imamura, Yorishige
Tetrahedron Asymmetry, 1998 , vol. 9, # 24 p. 4331 - 4340
反应条件
1: 1.) 1,8-diazabicyclo<5.4.0>undec-7-ene / 1.) benzene, RT, 30 min, 2.) benzene, RT, 1 h 2: 90 percent / K2CO3, MeOH / 12 h / Ambient temperature View Scheme
参考文献
Akita, Hiroyuki; Kurashima, Katsumi; Nozawa, Masako; Yamamura, Shigeo; Seri, Kenzi; Imamura, Yorishige
Tetrahedron Asymmetry, 1998 , vol. 9, # 24 p. 4331 - 4340
