N-苄氧羰基-L-异亮氨酸合成路线 （共 29 条）
反应条件
1: EDCI; DMAP / CH2Cl2 / 24 h / Heating 2: aq. NaOH / ethanol View Scheme
参考文献
Weygand,F. et al.
Chemische Berichte, 1966 , vol. 99, p. 1446 - 1450
反应条件
ammonia; triethylamine in dichloromethane
参考文献
LUCKY LTD.
Patent: EP601486 A1, 1994 ;
反应条件
hexamethylphosphorous triamide dichloride; ammonia in dichloromethane
1) 30 min, -20 deg C, 2) 4 h, r.t.;
参考文献
Appel, Rolf; Hiester, Ernst
Chemische Berichte, 1983 , vol. 116, # 5 p. 2037 - 2040
反应条件
1.1: ClCOOEt; N-methylmorpholine / tetrahydrofuran / 0.25 h / -15 °C
1.2: tetrahydrofuran; CH2Cl2 / -15 - 20 °C
2.1: 70 percent / CF3COOAg / dioxane; H2O / 0.5 h / sonication
View Scheme
参考文献
Hughes, Andrew B.; Sleebs, Brad E.
Helvetica Chimica Acta, 2006 , vol. 89, # 11 p. 2611 - 2637
反应条件
1: (i) ClCO2Et, Et3N, CHCl3, (ii) /BRN= 1722028/
2: aq. NaOH / acetone
3: H2, AcOH / Pd / methanol; H2O
View Scheme
参考文献
Okumura,Y.; Sakurai,A.
Bulletin of the Chemical Society of Japan, 1973 , vol. 46, p. 2190 - 2193
反应条件
1: (i) ClCO2Et, Et3N, CHCl3, (ii) /BRN= 1722028/
2: aq. NaOH / acetone
View Scheme
参考文献
Okumura,Y.; Sakurai,A.
Bulletin of the Chemical Society of Japan, 1973 , vol. 46, p. 2190 - 2193
反应条件
1: chlorocarbonic acid isobutyl ester; triethylamine; toluene / anschliessend Behandeln mit L-Tyrosin-benzylester-toluol-4-sulfonat
2: palladium; acetic acid; aqueous methanol / Hydrogenolyse
View Scheme
参考文献
Izumiya et al.
Nippon Kagaku Zasshi, 1958 , vol. 79, p. 420,423
Chem.Abstr., 1960 , p. 4408
反应条件
chloroform; chloroformic acid ethyl ester; triethylamine
anschliessend Behandeln mit L-Leucin-methylester und Behandeln des Reaktionsprodukts in Aethanol mit wss. NaOH;
参考文献
Okumura,Y.; Sakurai,A.
Bulletin of the Chemical Society of Japan, 1973 , vol. 46, p. 2190 - 2193
反应条件
1: 85 percent / triethylamine, chloroformic acid ethyl ester / CH2Cl2 / 1) -10 deg C, 1 h, 2) 2 h, room temperature
2: NaI / acetone
3: Zn, HgCl2 / acetone / 48 h / Heating
View Scheme
参考文献
Buchholz, Michael; Kunz, Horst
Liebigs Annalen der Chemie, 1983 , # 11 p. 1859 - 1885
