N-FMOC-L-甘氨酸合成路线 （共 36 条）
反应条件
1: POCl3 2: (i) 1,1'-carbonyldiimidazole, THF, (ii) /BRN= 3588613/, Et3N View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 1370 - 1387
反应条件
1: With triethylamine; trichlorophosphate in dichloromethane T=0°C; 2: With copper(I) oxide; 1,10-phenanthroline in tetrahydrofuran Heating; Further stages.;
参考文献
Bonin, Marc-Andre; Giguere, Denis; Roy, Rene
Tetrahedron, 2007 , vol. 63, # 23 p. 4912 - 4917
反应条件
(i) aq. NaNO2, HCO2H, (ii) H2O; Multistep reaction;
参考文献
Johnston,T.P. et al.
J. Med. Chem., 1963 , vol. 6, p. 669 - 681
反应条件
1: Lawesson's reagent / tetrahydrofuran / Heating
2: CH2Cl2 / 2 h / -78 - 0 °C
3: 46 percent / DBU / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Yokoyama; Menjo; Watanabe; Togo
Synthesis, 1994 , # 12 p. 1467 - 1470
反应条件
ethanol; hydrazine hydrate
参考文献
King et al.
Journal of the Chemical Society, 1954 , p. 1039,1042
反应条件
1.1: triethylamine; trichlorophosphate / dichloromethane / 1 h / -10 - 0 °C
1.2: 0.5 h / -20 - 20 °C
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; WROBLESKI, Stephen T.; JAGABANDHU, Das; DOWEYKO, Lidia M.; GUO, Junqing; HYNES, John; JIANG, Bin; KEMPSON, James; LIN, Shuqun; SPERGEL, Steven H.; TOKARSKI, John S.; WU, Hong; YANG, Bingwei Vera
Patent: WO2012/125887 A1, 2012 ;
WO 2012/125887 A1
