4,4-二甲氧基-2-甲基-2-丁醇合成路线 （共 17 条）
反应条件
(i) (heating), Py, (ii) (methylation); Multistep reaction;
参考文献
Bandaranayake,W.M. et al.
Journal of the Chemical Society [Section] D: Chemical Communications, 1969 , p. 970 - 971
反应条件
pyridine
T=220°C; 4 h; Microwave irradiation;
参考文献
Zhou, Ting; Shi, Qian; Lee, Kuo Hsing
Tetrahedron Letters, 2010 , vol. 51, # 33 p. 4382 - 4386
反应条件
pyridine
T=150°C; 10 h;
参考文献
Suzuki, Madoka; Yu, Donglei; Morris-Natschke, Susan L.; Smith, Philip C.; Lee, Kuo-Hsiung
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 21 p. 6852 - 6858
反应条件
1: 79 percent / pyridine / 48 h / 160 °C
2: 93 percent / K2CO3 / acetone / Heating
3: HBr / CCl4 / 0.25 h / 0 °C
4: Br2 / CCl4
5: Et3N / CCl4
6: 57 percent / DBU / Ambient temperature
View Scheme
参考文献
Palmer, Christopher J.; Josephs, Jonathan L.
Tetrahedron Letters, 1994 , vol. 35, # 30 p. 5363 - 5366
反应条件
1: 15 mg / pyridine / 24 h / 140 °C
2: 4 mg / BBr3 / CH2Cl2 / 1.) -40 to -30 deg C, 20 min, 2.) attain RT
View Scheme
参考文献
Bhatia, S. K.; Kapil, R. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 11 p. 1090 - 1092
反应条件
pyridine
T=220°C; 4 h; Microwave irradiation; regioselective reaction;
参考文献
Zhou, Ting; Shi, Qian; Lee, Kuo Hsing
Tetrahedron Letters, 2010 , vol. 51, # 33 p. 4382 - 4386
反应条件
pyridine
T=220°C; 4 h; Microwave irradiation; regioselective reaction;
参考文献
Zhou, Ting; Shi, Qian; Lee, Kuo Hsing
Tetrahedron Letters, 2010 , vol. 51, # 33 p. 4382 - 4386
