1,3,5-三氟-2-硝基苯合成路线 (共 25 条)
反应条件
sulfuric acid; nitric acid Ambient temperature;
参考文献
Barnard; Storr; O'Neill; Park
Journal of Pharmacy and Pharmacology, 1993 , vol. 45, # 8 p. 736 - 744
反应条件
potassium fluoride; dimethyl sulfoxide T=180°C;
参考文献
Journal of the American Chemical Society, , vol. 78, p. 6034,6037
反应条件
1: iron; aqueous NH4Cl 3: sulfuric acid; concentrated aqueous nitric acid View Scheme
参考文献
Journal of the American Chemical Society, , vol. 73, p. 153
Journal of the American Chemical Society, , vol. 81, p. 94,98
反应条件
1: sulfuric acid; aqueous phosphoric acid; nitrosylsulfuric acid / anschliessendes Behandeln mit Natriumhypophosphit-Loesung und Kupfer(I)-oxid 2: iron; aqueous NH4Cl 4: sulfuric acid; concentrated aqueous nitric acid View Scheme
参考文献
Journal of the American Chemical Society, , vol. 73, p. 153
Journal of the American Chemical Society, , vol. 81, p. 94,98
反应条件
2: sulfuric acid; concentrated aqueous nitric acid View Scheme
参考文献
Journal of the American Chemical Society, , vol. 73, p. 153
Journal of the American Chemical Society, , vol. 81, p. 94,98
反应条件
1: H2SO4; HNO3 2: sulfuric acid; aqueous phosphoric acid; nitrosylsulfuric acid / anschliessendes Behandeln mit Natriumhypophosphit-Loesung und Kupfer(I)-oxid 3: iron; aqueous NH4Cl 5: sulfuric acid; concentrated aqueous nitric acid View Scheme
参考文献
Journal of the American Chemical Society, , vol. 73, p. 153
Journal of the American Chemical Society, , vol. 81, p. 94,98
反应条件
ammonia in tetrahydrofuran
参考文献
Barvian, Kevin Karl; Speake, Jason Daniel; Cowan, David John; Larkin, Andrew Lamont; Szewczyk, Jerzy Ryszard
Patent: US2009/54431 A1, 2009 ;
Location in patent: Page/Page column 30-32 ;
反应条件
potassium carbonate in acetone T=50°C; 2 h;
参考文献
SANOFI
Patent: US2012/277220 A1, 2012 ;
Location in patent: Page/Page column 19 ;
参考文献
Barnard; Storr; O'Neill; Park
Journal of Pharmacy and Pharmacology, 1993 , vol. 45, # 8 p. 736 - 744
反应条件
tetrabutyl ammonium fluoride in dimethyl sulfoxide T=25°C; 0.166667 h; Inert atmosphereMicrowave irradiationAnhydrous conditions;
参考文献
Tetrahedron Letters, , vol. 51, # 14 p. 1906 - 1909