3,5-二溴-2-羟基苯甲酸合成路线 （共 79 条）
反应条件
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 25 °C / Inert atmosphere
2: triethylamine / tetrahydrofuran / 0 - 25 °C / Inert atmosphere
View Scheme
参考文献
Garner, Amanda L.; Gloeckner, Christian; Tricoche, Nancy; Zakhari, Joseph S.; Samje, Moses; Cho-Ngwa, Fidelis; Lustigman, Sara; Janda, Kim D.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 11 p. 3963 - 3972
反应条件
1: PCl3 / chlorobenzene / 0.25 h / Heating
2: chlorobenzene / 3 h / Heating
View Scheme
参考文献
Coburn; Batista; Evans; Genco
Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1245 - 1249
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
8 h; Reflux;
参考文献
Zhu, Zhen-Wei; Shi, Lei; Ruan, Xiao-Ming; Yang, Ying; Li, Huan-Qiu; Xu, Suo-Ping; Zhu, Hai-Liang
Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 1 p. 37 - 45
反应条件
phosphorus trichoride in chlorobenzene
3 h; Heating;
参考文献
Waisser, Karel; Hladuvkova, Jana; Gregor, Jiri; Rada, Tomas; Kubicova, Lenka; Klimesova, Vera; Kaustova, Jarmila
Archiv der Pharmazie, 1998 , vol. 331, # 1 p. 3 - 6
参考文献
Kurono; Yamada; Hata; Okada; Takeuchi; Ikeda
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3715 - 3719
参考文献
Robertson
Journal of the Chemical Society, 1902 , vol. 81, p. 1480
反应条件
phosphorus pentachloride; Petroleum ether
参考文献
Coburn; Batista; Evans; Genco
Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1245 - 1249
参考文献
Anschuetz,R.; Robitsek
Justus Liebigs Annalen der Chemie, 1906 , vol. 346, p. 311,329
反应条件
trichlorophosphate
T=75 - 80°C; 4 h;
参考文献
Petrlikova, Eva; Waisser, Karel; Palat Jr., Karel; Kunes, Jiri; Kaustova, Jarmila
Chemical Papers, 2011 , vol. 65, # 1 p. 52 - 59
