2-甲基-2,3-二氢苯并呋喃-7-羧酸合成路线 （共 12 条）
反应条件
1: 2-methyl-2,3-dihydrobenzofuran With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in hexane T=20°C; 1 h; 2: carbon dioxide T=-78°C;
参考文献
Al-bojuk, Nader R.; El-Abadelah, Mustafa M.; Sabri, Salim S.; Michel, Alain; Voelter, Wolfgang; M.-Moessmer, Caecilia; Al-Abed, Yousef
Heterocycles, 2001 , vol. 55, # 9 p. 1789 - 1803
反应条件
zirconium tetrachloride in dichloromethane T=20°C; 20 h;
参考文献
Meshram; Premalatha; Rameshbabu; Eeshwaraiah; Yadav
Synthetic Communications, 2004 , vol. 34, # 17 p. 3091 - 3097
反应条件
hydrogen bromide; acetic acid Erwaermen des Reaktionsprodukts mit wss. Natronlauge;
参考文献
Robertson, David W.; Lacefield, William B.; Bloomquist, William; Pfeifer, William; Simon, Richard L.; Cohen, Marlene L.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 310 - 319
反应条件
1: 210 - 215 °C View Scheme
参考文献
Stanetty, Peter; Koller, Herbert; Puerstinger, Gerhard
Monatshefte fuer Chemie, 1990 , vol. 121, # 11 p. 883 - 891
反应条件
1: K2CO3 / acetone / Heating 2: N-methylpyrrolidinone / 7 h / Heating 3: 90percent HCOOH / 3 h / Heating 4: NaOH / H2O / 3 h / Heating View Scheme
参考文献
Stanetty, Peter; Koller, Herbert; Puerstinger, Gerhard
Monatshefte fuer Chemie, 1990 , vol. 121, # 11 p. 883 - 891
反应条件
sodium hydroxide in water 3 h; Heating;
参考文献
Robertson, David W.; Lacefield, William B.; Bloomquist, William; Pfeifer, William; Simon, Richard L.; Cohen, Marlene L.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 310 - 319
反应条件
1: HCl (gas) / Heating 2: K2CO3 / acetone / Heating 3: N-methylpyrrolidinone / 7 h / Heating 4: 90percent HCOOH / 3 h / Heating 5: NaOH / H2O / 3 h / Heating View Scheme
参考文献
Robertson, David W.; Lacefield, William B.; Bloomquist, William; Pfeifer, William; Simon, Richard L.; Cohen, Marlene L.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 310 - 319
反应条件
1.1: conc. HCl; ZnCl2 / acetic acid / Heating 2.1: n-butyllithium; N,N,N',N'-tetramethylethylenediamine / hexane / 1 h / 20 °C 2.2: 67 percent / -78 °C View Scheme
参考文献
Al-bojuk, Nader R.; El-Abadelah, Mustafa M.; Sabri, Salim S.; Michel, Alain; Voelter, Wolfgang; M.-Moessmer, Caecilia; Al-Abed, Yousef
Heterocycles, 2001 , vol. 55, # 9 p. 1789 - 1803
反应条件
Yield given. Multistep reaction;
参考文献
Stanetty, Peter; Koller, Herbert; Puerstinger, Gerhard
Monatshefte fuer Chemie, 1990 , vol. 121, # 11 p. 883 - 891
反应条件
1: SOCl2 / toluene / 3 h / Heating 3: 42 percent / 2,3-dichlor-5,6-dicyano-1,4-benzochinon / 4 h / Heating 4: 98 percent / KOH / methanol; H2O / 3 h / Heating View Scheme
参考文献
Stanetty, Peter; Puerstinger, Gerhard
Journal of Chemical Research, Miniprint, 1991 , # 3 p. 581 - 594
