3-烯丙基-2-羟基苯甲酸甲酯合成路线 （共 36 条）
反应条件
1: aniline 2: K2CO3; acetone View Scheme
参考文献
Claisen
Justus Liebigs Annalen der Chemie, 1919 , vol. 418, p. 102
参考文献
Gomez
Journal de Pharmacie et de Chimie, 1934 , vol. <8> 20, p. 337,340
反应条件
1: aniline 2: K2CO3; acetone 3: beim Erhitzen in CO2-Atmosphaere 4: K2CO3; absolute alcohol View Scheme
参考文献
Claisen
Justus Liebigs Annalen der Chemie, 1919 , vol. 418, p. 102
反应条件
1: sodium methylate 2: methanolic NaOH-solution 3: 180 - 260 °C View Scheme
参考文献
Claisen
Justus Liebigs Annalen der Chemie, 1919 , vol. 418, p. 102
反应条件
hydrogen bromide; acetic acid Erwaermen des Reaktionsprodukts mit wss. Natronlauge;
参考文献
Robertson, David W.; Lacefield, William B.; Bloomquist, William; Pfeifer, William; Simon, Richard L.; Cohen, Marlene L.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 310 - 319
反应条件
Yield given. Multistep reaction;
参考文献
Stanetty, Peter; Koller, Herbert; Puerstinger, Gerhard
Monatshefte fuer Chemie, 1990 , vol. 121, # 11 p. 883 - 891
反应条件
1: NaH / 1) 20 min at 0 deg C 2) reflux for 12 h 2: NaOH / 1) 1h reflux with NaOH 2) concentrated HCl 3: SOCl2 4: 1) BF3*THF 2) NaOH, 30percent H2O2 / 2) at 55-60 deg C for 90 min 5: 72 percent / NaH / tetrahydrofuran / 20 h / Heating 6: 65 percent / 4.5M HCl / 18 h / Heating View Scheme
参考文献
Meyers, A. I.; Reuman, Michael; Gabel, Richard A.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 783 - 788
反应条件
1: NaH / 1) 20 min at 0 deg C 2) reflux for 12 h 2: NaOH / 1) 1h reflux with NaOH 2) concentrated HCl 3: SOCl2 4: 1) ozone 2) dimethyl sulfide / 1) 3 in MeOH at -78 deg C 2) room temperature overnight 5: 57 percent / NaBH4 / ethanol / 3 h 6: 95 percent / pyridine / 24 h 7: 63 percent / dimethylformamide / 13 h / 60 - 65 °C 8: 72 percent / hydrazine / 2-methyl-propan-2-ol / 3 h / Heating 9: 83.5 percent / diisopropylamine,n-BuLi / tetrahydrofuran / 1 h / -45 °C 10: 68 percent / 4.5M HCl / 30 h / Heating View Scheme
参考文献
Meyers, A. I.; Reuman, Michael; Gabel, Richard A.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 783 - 788
反应条件
1: aniline 2: bei der Einw. von Saeuren View Scheme
参考文献
Claisen
Justus Liebigs Annalen der Chemie, 1919 , vol. 418, p. 102
反应条件
hydrogen; nickel in ethyl acetate P=3102.9 Torr; 8 h; Ambient temperature;
参考文献
Zammattio; Brion; Le Baut; Ducrey
Synthesis, 1992 , # 4 p. 375 - 376
