4-乙基-4-羟基-3,4,12,14-四氢-1H-吡喃并[3'4':6,7]吲哚嗪并[1,2-b]喹啉-3,14-二酮合成路线 （共 79 条）
反应条件
1: DDQ / dioxane / Heating 2: (i) NaH, DMF, (ii) /BRN= 505934/ 3: O2, Cu(OAc)2, Et3N / dimethylformamide; methanol / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 22, # 4 p. 771 - 781
反应条件
(i) DDQ, (ii) LiBH4, aq. HCl; Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 94, # 10 p. 3631 - 3632
反应条件
1: 81.9 percent / 80percent aqueous trifluoroacetic acid / 3 h / Ambient temperature 2: 69.5 percent / 2) p-TsOH / toluene / Heating; 1) 30 min, 2) 3 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 1 p. 27 - 31
反应条件
1: (i) KCN, (ii) HCl, MeOH, (iii) HBr, AcOH, (iv) NaOMe, benzene 2: (i) DDQ, (ii) LiBH4, aq. HCl View Scheme
参考文献
Journal of the American Chemical Society, , vol. 94, # 10 p. 3631 - 3632
反应条件
1: (i) (iBu)2AlH, KBH4, 1,2-dimethoxy-ethane, (ii) CF3CO2H 2: (i) NaH, DMF, (ii) /BRN= 505934/ 3: CuCl2, O2, aq. Me2NH / dimethylformamide View Scheme
参考文献
Chemische Berichte, , vol. 105, p. 2126 - 2142
反应条件
(i) aq. HCl, (ii) O2, Cu(OAc)2, Et3N, MeOH, (iii) DDQ, dioxane; Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 22, # 4 p. 771 - 781
反应条件
(i) H2SO4, (ii) (oxidation); Multistep reaction;
参考文献
Tetrahedron Letters, , p. 1307 - 1310
反应条件
1: (i) NaH, DMF, (ii) /BRN= 505934/ 2: (i) aq. HCl, (ii) O2, Cu(OAc)2, Et3N, MeOH, (iii) DDQ, dioxane View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 22, # 4 p. 771 - 781
反应条件
in N,N-dimethyl-formamide; acetonitrile
参考文献
SmithKline Beecham Corporation
Patent: US5155225 A1, 1992 ;
