4-乙基-4-羟基-3,4,12,14-四氢-1H-吡喃并[3'4':6,7]吲哚嗪并[1,2-b]喹啉-3,14-二酮合成路线 （共 79 条）
反应条件
1: SOCl2, DMF / CHCl3 / Ambient temperature 2: acetonitrile; pyridine / 18 h / Ambient temperature 3: sodium acetate / acetic acid / Ambient temperature 4: sodium methoxide / methanol / 8 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 21 p. 3613 - 3616
反应条件
1: MnO2-HCl / -15 °C 2: SOCl2, DMF / CHCl3 / Ambient temperature 3: acetonitrile; pyridine / 18 h / Ambient temperature 4: sodium acetate / acetic acid / Ambient temperature 5: sodium methoxide / methanol / 8 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 21 p. 3613 - 3616
反应条件
1: TEA, ethyl chloroformate / CH2Cl2 / Ambient temperature 2: MnO2-HCl / -15 °C 3: SOCl2, DMF / CHCl3 / Ambient temperature 4: acetonitrile; pyridine / 18 h / Ambient temperature 5: sodium acetate / acetic acid / Ambient temperature 6: sodium methoxide / methanol / 8 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 21 p. 3613 - 3616
反应条件
1: sodium acetate / acetic acid / Ambient temperature 2: sodium methoxide / methanol / 8 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 21 p. 3613 - 3616
反应条件
1: acetonitrile; pyridine / 18 h / Ambient temperature 2: sodium acetate / acetic acid / Ambient temperature 3: sodium methoxide / methanol / 8 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 21 p. 3613 - 3616
反应条件
1: aq. HCl / Ambient temperature 2: DDQ / dioxane / Heating 3: (i) NaH, DMF, (ii) /BRN= 505934/ 4: O2, Cu(OAc)2, Et3N / dimethylformamide; methanol / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 22, # 4 p. 771 - 781
反应条件
1.1: 38 percent / SmI2 / tetrahydrofuran; methanol / 4 h / -78 °C 2.1: lithium hexamethyldisilazide / tetrahydrofuran; hexane / 1 h / -78 °C 2.2: 43 percent / copper(I) iodide; tert-butyl hydroperoxide; pyridine / tetrahydrofuran / 60 h / -78 °C View Scheme
参考文献
Heterocycles, , vol. 55, # 11 p. 2157 - 2170
反应条件
1.1: 94 percent / pyridine / 72 h / 20 °C 2.1: 38 percent / SmI2 / tetrahydrofuran; methanol / 4 h / -78 °C 3.1: lithium hexamethyldisilazide / tetrahydrofuran; hexane / 1 h / -78 °C 3.2: 43 percent / copper(I) iodide; tert-butyl hydroperoxide; pyridine / tetrahydrofuran / 60 h / -78 °C View Scheme
参考文献
Heterocycles, , vol. 55, # 11 p. 2157 - 2170
反应条件
1: NaNO2, HOAc / acetic anhydride / 4 h / 0 °C 2: CCl4 / 5 h / Heating 3: 33.5 percent / 1 M H2SO4 / 1,2-dimethoxy-ethane / 24 h / 55 °C 4: 69.5 percent / 2) p-TsOH / toluene / Heating; 1) 30 min, 2) 3 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 1 p. 27 - 31
反应条件
1: 33.5 percent / 1 M H2SO4 / 1,2-dimethoxy-ethane / 24 h / 55 °C 2: 69.5 percent / 2) p-TsOH / toluene / Heating; 1) 30 min, 2) 3 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 1 p. 27 - 31
