4-乙基-4-羟基-3,4,12,14-四氢-1H-吡喃并[3'4':6,7]吲哚嗪并[1,2-b]喹啉-3,14-二酮合成路线 （共 79 条）
反应条件
1: K2CO3 / CH2Cl2 2: 92 percent / NaH / tetrahydrofuran / 0.5 h / Ambient temperature 3: DDQ / dioxane / Heating 4: 81 percent / DIBAL-H / 2 h / -60 °C 5: DIBAL-H / tetrahydrofuran / 0 °C 6: 92 percent / CuCl2, (CH3)2NH, O2 / 20 h View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 37 p. 6745 - 6748
反应条件
1: HCl 2: K2CO3 / CH2Cl2 3: 92 percent / NaH / tetrahydrofuran / 0.5 h / Ambient temperature 4: DDQ / dioxane / Heating 5: 81 percent / DIBAL-H / 2 h / -60 °C 6: DIBAL-H / tetrahydrofuran / 0 °C 7: 92 percent / CuCl2, (CH3)2NH, O2 / 20 h View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 37 p. 6745 - 6748
反应条件
1: DIBAL-H / tetrahydrofuran / 0 °C 2: 92 percent / CuCl2, (CH3)2NH, O2 / 20 h View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 37 p. 6745 - 6748
反应条件
1: DDQ / dioxane / Heating 2: 81 percent / DIBAL-H / 2 h / -60 °C 3: DIBAL-H / tetrahydrofuran / 0 °C 4: 92 percent / CuCl2, (CH3)2NH, O2 / 20 h View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 37 p. 6745 - 6748
反应条件
1: 81 percent / DIBAL-H / 2 h / -60 °C 2: DIBAL-H / tetrahydrofuran / 0 °C 3: 92 percent / CuCl2, (CH3)2NH, O2 / 20 h View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 37 p. 6745 - 6748
反应条件
1: TEA / CH2Cl2 2: 82 percent / ammonia / methanol 3: acetonitrile; pyridine / 18 h / Ambient temperature 4: sodium acetate / acetic acid / Ambient temperature 5: sodium methoxide / methanol / 8 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 21 p. 3613 - 3616
反应条件
1: 82 percent / ammonia / methanol 2: acetonitrile; pyridine / 18 h / Ambient temperature 3: sodium acetate / acetic acid / Ambient temperature 4: sodium methoxide / methanol / 8 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 21 p. 3613 - 3616
反应条件
1: LiAlH4 / tetrahydrofuran / Ambient temperature 2: TEA / CH2Cl2 3: 82 percent / ammonia / methanol 4: acetonitrile; pyridine / 18 h / Ambient temperature 5: sodium acetate / acetic acid / Ambient temperature 6: sodium methoxide / methanol / 8 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 21 p. 3613 - 3616
反应条件
1: 2.) H2SO4 / 1.) MeOH, reflux; 2.) MeOH, CHCl3, reflux 2: LiAlH4 / tetrahydrofuran / Ambient temperature 3: TEA / CH2Cl2 4: 82 percent / ammonia / methanol 5: acetonitrile; pyridine / 18 h / Ambient temperature 6: sodium acetate / acetic acid / Ambient temperature 7: sodium methoxide / methanol / 8 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 21 p. 3613 - 3616
反应条件
1: acetonitrile; pyridine / 18 h / Ambient temperature 2: sodium acetate / acetic acid / Ambient temperature 3: sodium methoxide / methanol / 8 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 21 p. 3613 - 3616
