sodium tetrahydroborate; acetic acid in chloroform T=0 - 20°C; 13 h;

triethylamine in ethanol T=0 - 20°C;

sodium iodide in acetone T=60°C; 10.5 h;

in methanol; diethyl ether; toluene T=20°C; 21.1667 h;

C52H67ClFeNPPd; caesium carbonate in tetrahydrofuran; water T=80°C; Suzuki-Miyaura cross-coupling; 12 h;

toluene-4-sulfonic acid 48 h; Heating;

1: 1-methyl-piperazine With formic acid 0.25 h; cooling; 2: 4-formylbenzoic acid methyl ester T=180 - 200°C; Leuckart-Wallach reaction; 8 h; Further stages.;

1: 4-methyl-n3-(4-pyridin-3-yl-thiazol-2-yl)-benzene-1,3-diamine With trimethylaluminum in hexane; dichloromethane T=5 - 15°C; 2 h; 2: 4-(4-methyl-piperazin-1-methyl)-benzoic acid methyl ester in hexane; dichloromethane T=20°C; 21.1667 h; Heating / reflux; 3: With sodium hydroxide; water in hexane; dichloromethane T=20°C; 3 h; Product distribution / selectivity;

暂无反应条件数据

sodium methylate in tetrahydrofuran T=70°C;