反应条件
1: 3,4,5-trimethoxyphenylboronic acid With tris-(dibenzylideneacetone)dipalladium(0); sodium carbonate; triphenylphosphine in toluene
T=20°C; Suzuki coupling; Inert atmosphere;
2: 3,4-Dibromo-thiophene in toluene
Suzuki coupling; Inert atmosphere;
3: With sodium carbonate in toluene
T=20°C; Inert atmosphereReflux;
参考文献
Wang, Pengcheng; Min, Jian; Nwachukwu, Jerome C.; Cavett, Valerie; Carlson, Kathryn E.; Guo, Pu; Zhu, Manghong; Zheng, Yangfan; Dong, Chune; Katzenellenbogen, John A.; Nettles, Kendall W.; Zhou, Hai-Bing
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2324 - 2341