2-氯-4,6-二甲氧基-1,3,5-三嗪合成路线 （共 40 条）
反应条件
4-methyl-morpholine in N-methyl-acetamide; sodium hydroxide; ethanol
参考文献
Eli Lilly and Company
Patent: US5008391 A1, 1991 ;
反应条件
triethylamine in isopropyl alcohol T=20°C; Eschenmoser Methylenation; 0.25 h; Reagent/catalystSolvent;
参考文献
Tetrahedron Letters, , vol. 54, # 13 p. 1758 - 1760
反应条件
triethylamine in N,N-dimethyl-formamide T=20°C; Eschenmoser Methylenation; 0.25 h; Reagent/catalyst;
参考文献
Tetrahedron Letters, , vol. 54, # 13 p. 1758 - 1760
反应条件
1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-[1,3,5]triazine in tetrahydrofuran
T=0 - 5°C; 0.5 h;
2: (4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid in tetrahydrofuran
T=0 - 20°C; 12 h;
参考文献
AGROPHARM S.A.
Patent: WO2004/56790 A1, 2004 ;
Location in patent: Page 12 ;
反应条件
1: 2-chloro-4,6-dimethoxy-[1,3,5]triazine; 3-phenylpropionic acid With trimethylamine in dichloromethane
T=20°C; 1 h;
2: phenethylamine in dichloromethane
T=20°C; 3 h;
参考文献
Kunishima, Munetaka; Ujigawa, Takae; Nagaoka, Yoshie; Kawachi, Chiho; Hioki, Kazuhito; Shiro, Motoo
Chemistry - A European Journal, 2012 , vol. 18, # 49 p. 15856 - 15867
反应条件
N-benzyl-2-(dimethylamino)acetamide in methanol
T=20°C;
参考文献
Kitamura, Masanori; Kawasaki, Fumitaka; Ogawa, Kouichi; Nakanishi, Shuichi; Tanaka, Hiroyuki; Yamada, Kohei; Kunishima, Munetaka
Journal of Organic Chemistry, 2014 , vol. 79, # 8 p. 3709 - 3714
反应条件
sodium carbonate; 1-(1-benzyl-1H-1,2,3-triazol-4-yl)-N,N-dimethylmethanamine, in methanol
T=20°C; 3 h; Reagent/catalyst;
参考文献
Kitamura, Masanori; Kawasaki, Fumitaka; Ogawa, Kouichi; Nakanishi, Shuichi; Tanaka, Hiroyuki; Yamada, Kohei; Kunishima, Munetaka
Journal of Organic Chemistry, 2014 , vol. 79, # 8 p. 3709 - 3714
反应条件
1: 2-chloro-4,6-dimethoxy-[1,3,5]triazine; N,N,N',N'-tetramethylguanidine in acetonitrile
T=0 - 5°C; 0.5 h;
2: C25H23NO6 in acetonitrile
12 h;
参考文献
AGROPHARM S.A.
Patent: WO2004/56790 A1, 2004 ;
Location in patent: Page 9 ;
反应条件
Cl2Ni(1,2-bis(diphenylphosphino)ethane) in diethyl ether
T=25°C; Kumada cross-coupling; 2 h;
参考文献
Samaritani, Simona; Signore, Giovanni; Malanga, Corrado; Menicagli, Rita
Tetrahedron, 2005 , vol. 61, # 18 p. 4475 - 4483
反应条件
bis-triphenylphosphine-palladium(II) chloride in diethyl ether
4 h; Heating;
参考文献
Samaritani, Simona; Signore, Giovanni; Malanga, Corrado; Menicagli, Rita
Tetrahedron, 2005 , vol. 61, # 18 p. 4475 - 4483
