2,3,4,6-四氟硝基苯合成路线 （共 10 条）
反应条件
2CF3SO3H-B(OSO2CF3)3; nitric acid T=20°C; 3 h;
参考文献
Olah, George A.; Orlinkov, Alexander; Oxyzoglou, Alexandros B.; Prakash, G. k. Surya
Journal of Organic Chemistry, 1995 , vol. 60, # 22 p. 7348 - 7350
反应条件
hydrogen; palladium on activated charcoal
参考文献
Coe,P.L. et al.
Journal of the Chemical Society [Section] C: Organic, 1966 , p. 2323 - 2324
反应条件
1: 95 percent / NH3 / diethyl ether 2: 0.324 g / H2 / Pd/C / ethanol View Scheme
参考文献
Burdon, James; Fisher, Derek; Parsons Ian W.; Tatlow, John Colin
Journal of Fluorine Chemistry, 1981 , vol. 18, p. 507 - 514
反应条件
sulfuric acid; periodic acid; potassium iodide
T=0 - 50°C; 4 h;
参考文献
Sander, Wolfram; Winkler, Michael; Cakir, Bayram; Grote, Dirk; Bettinger, Holger F.
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 715 - 724
反应条件
1: 1-amino-2-fluoro-4-iodobenzene With lithium hexamethyldisilazane in tetrahydrofuran
T=-78°C; 1 h;
2: 2,3,4,6-tetrafluoronitrobenzene in tetrahydrofuran
T=-78 - 20°C; 16 h;
参考文献
VALEANT RESEARCH and DEVELOPMENT
Patent: WO2007/14011 A2, 2007 ;
Location in patent: Page/Page column 73; 74 ;
WO 2007/014011 A2
反应条件
lithium hexamethyldisilazane in tetrahydrofuran
T=-78 - 20°C; 16 h;
参考文献
ARDEA BIOSCIENCES
Patent: US2007/238710 A1, 2007 ;
Location in patent: Page/Page column 46 ;
US 20070238710 A1
反应条件
1.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h / -78 °C
1.2: 1 h / 20 °C
2.1: tetrahydrofuran / -78 - 20 °C
View Scheme
参考文献
NOVARTIS AG; BOCK, Mark G.; CHIKKANNA, Dinesh; MCCARTHY, Clive; MOEBITZ, Henrik; PANDIT, Chetan; PODDUTOORI, Ramulu
Patent: WO2011/70030 A1, 2011 ;
WO 2011/070030 A1
反应条件
1: 92 percent / H5IO6; H2SO4; KI / 4 h / 0 - 50 °C
2: 81 percent / hydrogen / palladium on carbon / methanol / 1 h / 3000.24 Torr
View Scheme
参考文献
Sander, Wolfram; Winkler, Michael; Cakir, Bayram; Grote, Dirk; Bettinger, Holger F.
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 715 - 724
反应条件
1: 92 percent / H5IO6; H2SO4; KI / 4 h / 0 - 50 °C
2: 81 percent / hydrogen / palladium on carbon / methanol / 1 h / 3000.24 Torr
3: 84 percent / trifluoroacetic acid; sodium nitrite / H2O / 0.5 h / -5 °C
View Scheme
参考文献
Sander, Wolfram; Winkler, Michael; Cakir, Bayram; Grote, Dirk; Bettinger, Holger F.
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 715 - 724
反应条件
ammonia in diethyl ether
参考文献
Burdon, James; Fisher, Derek; Parsons Ian W.; Tatlow, John Colin
Journal of Fluorine Chemistry, 1981 , vol. 18, p. 507 - 514
