1-(2-羟基苯基)-哌嗪-4-羧酸叔丁酯合成路线 （共 5 条）
反应条件
in tetrahydrofuran T=60°C; 6 h;
参考文献
REVIVA PHARMACEUTICALS, INC.
Patent: US2009/298819 A1, 2009 ;
Location in patent: Page/Page column 18; 25 ;
US 20090298819 A1
反应条件
triethylamine in 1,4-dioxane; water
参考文献
Biovitrum AB
Patent: US6465467 B1, 2002 ;
US 6465467 B1
反应条件
1: 18-crown-6 ether; potassium carbonate / acetonitrile / 20 h / Reflux 2: palladium diacetate; caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / 1,4-dioxane / 20 h / Reflux 3: 5 Pd(II)/C(eggshell); hydrogen / 2 h / 20 °C View Scheme
参考文献
Hoveyda, Hamid R.; Roy, Marie-Odile; Blanc, Sebastien; Noel, Sophie; Salvino, Joseph M.; Ator, Mark A.; Fraser, Graeme
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 7 p. 1991 - 1996
反应条件
1: palladium diacetate; caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / 1,4-dioxane / 20 h / Reflux 2: 5 Pd(II)/C(eggshell); hydrogen / 2 h / 20 °C View Scheme
参考文献
Hoveyda, Hamid R.; Roy, Marie-Odile; Blanc, Sebastien; Noel, Sophie; Salvino, Joseph M.; Ator, Mark A.; Fraser, Graeme
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 7 p. 1991 - 1996
反应条件
5 Pd(II)/C(eggshell); hydrogen T=20°C; 2 h;
参考文献
Hoveyda, Hamid R.; Roy, Marie-Odile; Blanc, Sebastien; Noel, Sophie; Salvino, Joseph M.; Ator, Mark A.; Fraser, Graeme
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 7 p. 1991 - 1996
