2,4-二甲基二苯并噻吩合成路线 （共 11 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; pivalic acid potassium salt in N,N-dimethyl acetamide T=140°C; 12 h;
参考文献
Saravanan, Perumal; Anbarasan, Pazhamalai
Organic Letters, 2014 , vol. 16, # 3 p. 848 - 851
反应条件
boron trifluoride diethyl etherate in acetonitrile T=45°C; 4 h;
参考文献
Shang, Xiaobo; Chen, Wanzhi; Yao, Yingming
Synlett, 2013 , vol. 24, # 7 art. no. ST-2013-W0104-L, p. 851 - 854
反应条件
selenium T=300°C; 8 h;
参考文献
Tedjamulia, Marvin L.; Tominaga, Yoshinori; Castle, Raymond N.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1485 - 1495
反应条件
1.1: sulfuryl dichloride; triethylamine / dichloromethane / 0 - 20 °C 1.2: 1 h / 0 - 20 °C 2.1: palladium diacetate; trifluoroacetic acid / 0.75 h / 20 °C 3.1: pivalic acid potassium salt; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl acetamide / 12 h / 140 °C View Scheme
参考文献
Saravanan, Perumal; Anbarasan, Pazhamalai
Organic Letters, 2014 , vol. 16, # 3 p. 848 - 851
反应条件
1: palladium diacetate; trifluoroacetic acid / 0.75 h / 20 °C 2: pivalic acid potassium salt; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl acetamide / 12 h / 140 °C View Scheme
参考文献
Saravanan, Perumal; Anbarasan, Pazhamalai
Organic Letters, 2014 , vol. 16, # 3 p. 848 - 851
反应条件
1: 84 percent / NaOH / aq. ethanol / r.t., 30min., then reflux, 4h 2: 80 percent / polyphosphoric acid / 1.5 h / 190 - 200 °C 3: 75 percent / Se powder / 8 h / 300 °C View Scheme
参考文献
Tedjamulia, Marvin L.; Tominaga, Yoshinori; Castle, Raymond N.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1485 - 1495
反应条件
1: 84 percent / NaOH / aq. ethanol / r.t., 30min., then reflux, 4h 2: 80 percent / polyphosphoric acid / 1.5 h / 190 - 200 °C 3: 75 percent / Se powder / 8 h / 300 °C View Scheme
参考文献
Tedjamulia, Marvin L.; Tominaga, Yoshinori; Castle, Raymond N.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1485 - 1495
反应条件
1: 93 percent / LiAlH4 / diethyl ether / 3 h / Heating 2: 84 percent / NaOH / aq. ethanol / r.t., 30min., then reflux, 4h 3: 80 percent / polyphosphoric acid / 1.5 h / 190 - 200 °C 4: 75 percent / Se powder / 8 h / 300 °C View Scheme
参考文献
Tedjamulia, Marvin L.; Tominaga, Yoshinori; Castle, Raymond N.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1485 - 1495
反应条件
1: 1. conc. hydrochloric acid, NaNO2; / 1. 0 degC, 30min.; 2. 40 - 45 degC 2: 93 percent / LiAlH4 / diethyl ether / 3 h / Heating 3: 84 percent / NaOH / aq. ethanol / r.t., 30min., then reflux, 4h 4: 80 percent / polyphosphoric acid / 1.5 h / 190 - 200 °C 5: 75 percent / Se powder / 8 h / 300 °C View Scheme
参考文献
Tedjamulia, Marvin L.; Tominaga, Yoshinori; Castle, Raymond N.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1485 - 1495
反应条件
1.1: hydrogenchloride / acetonitrile; water / 0.25 h / -10 - 20 °C 1.2: 0.5 h 1.3: 0.5 h / -10 - 20 °C 2.1: caesium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,4-dioxane / 100 °C / |Inert atmosphere 3.1: boron trifluoride diethyl etherate / acetonitrile / 4 h / 45 °C View Scheme
参考文献
Shang, Xiaobo; Chen, Wanzhi; Yao, Yingming
Synlett, 2013 , vol. 24, # 7 art. no. ST-2013-W0104-L, p. 851 - 854
