4-甲氧基-2-甲基苯甲酰氯合成路线 （共 5 条）
反应条件
thionyl chloride Heating;
参考文献
Hartmann; Vom Orde; Schonenberger
Archiv der Pharmazie, 1990 , vol. 323, # 2 p. 73 - 78
反应条件
1: 70 percent / Br2, NaOH / H2O / 2 h / Ambient temperature 2: 78 percent / SOCl2 / Heating View Scheme
参考文献
Hartmann; Vom Orde; Schonenberger
Archiv der Pharmazie, 1990 , vol. 323, # 2 p. 73 - 78
反应条件
ammonia in tetrahydrofuran; water T=30°C; 0.25 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/161670 A1, 2007 ;
Location in patent: Page/Page column 3-4 ;
反应条件
1: Et3N / CH2Cl2 / 2 h
2: 37percent aq. HCl / 0.5 h
3: 1.) MeCN, reflux, 1 h, 2.) 110 deg C, 2 h
4: 0.17 h / 200 °C
View Scheme
参考文献
Omodei-Sale, Amedeo; Consonni, Pietro; Galliani, Giulio
Journal of Medicinal Chemistry, 1983 , vol. 26, # 8 p. 1187 - 1192
反应条件
hydrogenchloride in dichloromethane
参考文献
Kovalskiy; Perevalov
Chemistry of Heterocyclic Compounds, 2009 , vol. 45, # 12 p. 1503 - 1507
