3,5-二甲基异噁唑-4-甲酰氯合成路线 （共 14 条）
参考文献
Tetrahedron, , vol. 28, p. 3295 - 3297
Journal of Organic Chemistry, , vol. 22, p. 559
DE634286 , ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 23, p. 502
CH185280 , ;
反应条件
1: 96 percent / CH2Cl2 / 24 h 2: 1.) n-butyl lithium / 1.) THF, hexane, -40 deg C, 1.5 h, 2.) THF, RT, 8 h View Scheme
参考文献
Niou, Chorng-Shyr; Natale, Nicholas R.
Heterocycles, 1986 , vol. 24, # 2 p. 401 - 412
反应条件
1: 70 percent / benzene / 8 h / Heating 2: 100 percent / H2 / W-2 Raney nickel / ethanol / 2327.2 - 2585.7 Torr / Ambient temperature View Scheme
参考文献
Caronna, Sergio; Migliara, Onofrio; Petruso, Salvatore
Heterocycles, 1986 , vol. 24, # 5 p. 1377 - 1380
参考文献
Hoffmann-La Roche
Patent: DE634286 , 1935 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 23, p. 502
Full Text Show Details
Hoffmann-La Roche
Patent: CH185280 , 1936 ;
反应条件
1: aq. NH3 2: SOCl2 / Heating View Scheme
参考文献
Kochetkov,N.K. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1962 , vol. 32, p. 1778 - 1785,1763 - 1769
参考文献
University of California; Yissum Research Development Company of the Hebrew University of Jerusalem; Biosignal LTD; Sugen, Inc.; Max-Planck-Gesellschaft zur Forderung der Wissenschaften E.V.
Patent: US6331555 B1, 2001 ;
US 6331555 B1
反应条件
1.1: pyridine / dichloromethane / 20 °C 1.2: 1 h / 20 °C 2.1: tetrahydrofuran / 4 h / 0 - 20 °C 2.2: 1 h / 20 °C View Scheme
参考文献
SANOFI; EL-AHMAD, Youssef; FILOCHE-ROMME, Bruno; GANZHORM, Axel; MARCINIAK, Gilbert; MUZET, Nicolas; RONAN, Baptiste; VIVET, Bertrand; ZERR, Véronique
Patent: WO2013/190123 A1, 2013 ;
反应条件
1: CHCl3 / 0 - 20 °C
2: thionyl chloride / CHCl3 / 0 - 20 °C
3: 1.) LDA / 1.) THF, -5 deg C, 30 min, 2.) THF, from -5 deg C to RT, overnight
4: 62 percent / 3 N aq. HCl / Heating
View Scheme
参考文献
Natale, N. R.; McKenna, John I.; Niou, Chorng-Shyr; Borth, Mark; Hope, Hakon
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5660 - 5666
参考文献
Dannhardt; Kiefer; Lambrecht; Laufer; Mutschler; Schweiger; Striegel
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 11 p. 839 - 850
参考文献
Hoffmann-La Roche
Patent: DE634286 , 1935 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 23, p. 502
