2-氨基-3-(三氟甲基)苯甲酸合成路线 （共 12 条）
反应条件
sodium hydroxide; dihydrogen peroxide
参考文献
Proceedings of the Royal Society of London, Series B: Biological Sciences, , vol. 148, p. 481,488
Journal of Organic Chemistry, , vol. 22, p. 29,32
反应条件
1: conc. H2SO4 / 60 - 80 °C 2: 5percent aq. NaOH, 30percent H2O2 / 0.5 h / 50 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 29, # 10 p. 743 - 751
反应条件
dihydrogen peroxide; sodium methylate 1.) 0-10 deg C 2.) room temperature, 30 min; Yield given. Multistep reaction;
参考文献
Angewandte Chemie, , vol. 93, # 10 p. 914 - 915
参考文献
DE693610 , ;
DRP/DRBP Org.Chem.
反应条件
(i) NaNO2, H2SO4, (ii) CuCl, aq. HCl; Multistep reaction;
参考文献
Fuller; Molloy; Day; Roush; Marsh
Journal of medicinal chemistry, 1973 , vol. 16, # 2 p. 101 - 106
反应条件
1: (i) NaNO2, H2SO4, (ii) CuCl, aq. HCl 2: (i) (COCl)2, (ii) NH3 3: BH3 View Scheme
参考文献
Fuller; Molloy; Day; Roush; Marsh
Journal of medicinal chemistry, 1973 , vol. 16, # 2 p. 101 - 106
反应条件
hydrogenchloride in methanol
参考文献
Roussel Uclaf
Patent: US4107310 A1, 1978 ;
反应条件
1: With hydrogenchloride in water
T=0°C; 0.416667 h; Cooling with ice;
2: With sodium nitrite in water
0.166667 h;
3: With potassium iodide in water
T=20°C; 16 h;
参考文献
Guilbault, Audrey-Anne; Basdevant, Benoit; Wanie, Vincent; Legault, Claude Y.
Journal of Organic Chemistry, 2012 , vol. 77, # 24 p. 11283 - 11295
参考文献
Clemence, Francois; Martret, Odile Le; Collard, Jeannine
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1345 - 1353
参考文献
Clemence, Francois; Martret, Odile Le; Collard, Jeannine
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1345 - 1353
