2-溴-3-甲基萘-1,4-二酮合成路线 （共 18 条）
反应条件
triethylamine in acetonitrile Ambient temperature;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 8 p. 2163 - 2174
反应条件
triethylamine in acetonitrile 10 h;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 8 p. 2163 - 2174
反应条件
1.1: 98 percent / SnCl2*2H2O; aq. HCl / ethanol 2.1: 88 percent / aq. KOH / 1 h / Heating 3.1: n-BuLi / tetrahydrofuran / -78 °C 3.2: B(OMe)3 / tetrahydrofuran / -78 - 20 °C 4.1: 100 percent / aq. Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; ethanol / 42 h / Heating 5.1: 81 percent / aq. CAN / acetonitrile / 0.08 h / 20 °C 6.1: 82 percent / t-BuOK / dimethylformamide / 0.17 h / 80 °C / Irradiation View Scheme
参考文献
Pathak, Rakhi; Vandayar, Kantharuby; Van Otterlo, Willem A. L.; Michael, Joseph P.; Fernandes, Manuel A.; De Koning, Charles B.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 23 p. 3504 - 3509
反应条件
1.1: 98 percent / SnCl2*2H2O; aq. HCl / ethanol 2.1: 88 percent / aq. KOH / 1 h / Heating 3.1: n-BuLi / tetrahydrofuran / -78 °C 3.2: B(OMe)3 / tetrahydrofuran / -78 - 20 °C 4.1: 100 percent / aq. Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; ethanol / 42 h / Heating 5.1: 87 percent / t-BuOK / dimethylformamide / 80 °C / Irradiation View Scheme
参考文献
Pathak, Rakhi; Vandayar, Kantharuby; Van Otterlo, Willem A. L.; Michael, Joseph P.; Fernandes, Manuel A.; De Koning, Charles B.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 23 p. 3504 - 3509
反应条件
in methanol
1 h; Ambient temperature;
参考文献
Ohta; Hinata; Yamashita; Kawasaki; Jinda; Horie
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 9 p. 1730 - 1735
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide in 1,4-dioxane
T=80°C; Stille coupling; 7 h; Inert atmosphere;
参考文献
Azuma, Shuhei; Nishio, Kazuyuki; Kubo, Konomi; Sasamori, Takahiro; Tokitoh, Norihiro; Kuramochi, Kouji; Tsubaki, Kazunori
Journal of Organic Chemistry, 2012 , vol. 77, # 10 p. 4812 - 4820
反应条件
1.1: 98 percent / SnCl2*2H2O; aq. HCl / ethanol
2.1: 88 percent / aq. KOH / 1 h / Heating
3.1: n-BuLi / tetrahydrofuran / -78 °C
3.2: B(OMe)3 / tetrahydrofuran / -78 - 20 °C
4.1: 100 percent / aq. Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; ethanol / 42 h / Heating
View Scheme
参考文献
Pathak, Rakhi; Vandayar, Kantharuby; Van Otterlo, Willem A. L.; Michael, Joseph P.; Fernandes, Manuel A.; De Koning, Charles B.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 23 p. 3504 - 3509
反应条件
1.1: 98 percent / SnCl2*2H2O; aq. HCl / ethanol
2.1: 88 percent / aq. KOH / 1 h / Heating
3.1: n-BuLi / tetrahydrofuran / -78 °C
3.2: B(OMe)3 / tetrahydrofuran / -78 - 20 °C
4.1: 100 percent / aq. Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; ethanol / 42 h / Heating
5.1: 81 percent / aq. CAN / acetonitrile / 0.08 h / 20 °C
View Scheme
参考文献
Pathak, Rakhi; Vandayar, Kantharuby; Van Otterlo, Willem A. L.; Michael, Joseph P.; Fernandes, Manuel A.; De Koning, Charles B.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 23 p. 3504 - 3509
反应条件
in N,N-dimethyl-formamide
T=20°C; 15 h;
参考文献
Araki, Shuki; Katsumura, Nobuhito; Butsugan, Yasuo
Journal of Organometallic Chemistry, 1991 , vol. 415, # 1 p. 7 - 24
反应条件
in formamide
T=80°C; 68 h;
参考文献
Hagiwara, Emiko
Tetrahedron Letters, 1995 , vol. 36, # 16 p. 2773 - 2776
