2',3',5'-三-O-乙酰基-8-溴腺苷合成路线 （共 6 条）
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine T=20°C; 5 h;
参考文献
LAURAS AS; COCKBAIN, Julian
Patent: WO2005/123755 A2, 2005 ;
Location in patent: Page/Page column 21; 42 ;
反应条件
potassium permanganate in water; acetic acid T=40°C; 0.17 h;
参考文献
Tetrahedron Letters, , vol. 22, # 33 p. 3205 - 3208
反应条件
disodium hydrogenphosphate; bromine in 1,4-dioxane 0.25 h; Ambient temperature;
参考文献
Maki, Yoshifumi; Makino, Toru; Hirota, Kosaku; Sako, Magoichi
Heterocycles, 1993 , vol. 35, # 1 p. 325 - 337
反应条件
1: palladium (II) acetate, triphenylarsine, triethylamine / various solvent(s) / 80 °C 2: 30percent NH3 MeOH, dioxane / Ambient temperature View Scheme
参考文献
Verlinde, Christophe L. M. J.; Callens, Mia; Calenbergh, Serge Van; Aerschot, Arthur Van; Herdewijn, Piet; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 21 p. 3605 - 3613
反应条件
di-tert-butyl peroxide in neat (no solvent) T=140°C; 24 h; Sealed tube; regioselective reaction;
参考文献
Xia, Ran; Niu, Hong-Ying; Qu, Gui-Rong; Guo, Hai-Ming
Organic Letters, 2012 , vol. 14, # 21 p. 5546 - 5549
反应条件
1: palladium (II) acetate, triphenylarsine, triethylamine / various solvent(s) / 80 °C
2: 30percent NH3 in MeOH/dioxane / Ambient temperature
View Scheme
参考文献
Verlinde, Christophe L. M. J.; Callens, Mia; Calenbergh, Serge Van; Aerschot, Arthur Van; Herdewijn, Piet; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 21 p. 3605 - 3613
