反应条件
1: NaBH4 / methanol / 1.) RT, 2 d, 2.) reflux, 3 h
2: H2, AcOH / 5percent Pd/C / 0.67 h / 1551.4 Torr
3: AlCl3 / CH2Cl2 / -18 - -12 °C
4: BBr3 / CH2Cl2 / 1.) 0 deg C, 2 h, 2.) RT, 15 h
View Scheme
参考文献
Herron, David K.; Goodson, Theodore; Bollinger, Nancy G.; Swanson-Bean, Dorothy; Wright, Ian G.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1818 - 1828
