bis-triphenylphosphine-palladium(II) chloride; triethylamine; lithium chloride in N,N-dimethyl-formamide T=90°C; Heck reaction; P=41254.1 Torr; 20 h;

bis-triphenylphosphine-palladium(II) chloride; lithium chloride in N,N-dimethyl-formamide T=20°C; vinylation; 14 h;

1: 64 percent / PPh3; DEAD / diethyl ether / 3 h / 20 °C 2: 92 percent / CH2Cl2; pyridine / 3 h / 0 °C 3: 93 percent / LiCl; Et3N; PdCl2(PPh3)2 / dimethylformamide / 20 h / 90 °C / 41254.1 Torr View Scheme

1: 77 percent / diethyl ether; tetrahydrofuran / -78 - 20 °C 2: 64 percent / PPh3; DEAD / diethyl ether / 3 h / 20 °C 3: 92 percent / CH2Cl2; pyridine / 3 h / 0 °C 4: 93 percent / LiCl; Et3N; PdCl2(PPh3)2 / dimethylformamide / 20 h / 90 °C / 41254.1 Torr View Scheme

1: 77 percent / diethyl ether; tetrahydrofuran / -78 - 20 °C 2: 64 percent / PPh3; DEAD / diethyl ether / 3 h / 20 °C 3: 92 percent / CH2Cl2; pyridine / 3 h / 0 °C 4: 93 percent / LiCl; Et3N; PdCl2(PPh3)2 / dimethylformamide / 20 h / 90 °C / 41254.1 Torr View Scheme

1: 92 percent / CH2Cl2; pyridine / 3 h / 0 °C 2: 93 percent / LiCl; Et3N; PdCl2(PPh3)2 / dimethylformamide / 20 h / 90 °C / 41254.1 Torr View Scheme