3-甲基-4-硝基苯甲酸合成路线 （共 68 条）
反应条件
1: 74.3 percent / sulfuric acid / 2 h / Heating 2: 92.1 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 3: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C 4: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C 5: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C View Scheme
参考文献
Yang, Ling-Chun; Qi, Chuan-Min; Zhang, Guan-Xin; Zou, Nan-Zhi
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1107 - 1112
参考文献
Imperial Chemical Industries PLC
Patent: US4388472 A1, 1983 ;
反应条件
1: tin; hydrochloric acid 2: alcohol; nitrous acid / Diazotization.Kochen der Diazoverbindung mit konz. Salzsaeure View Scheme
参考文献
Beilstein; Kreusler
Justus Liebigs Annalen der Chemie, 1867 , vol. 144, p. 182
反应条件
1: HCl / 6 h / 80 °C 2: dimethylformamide / 6.5 h / 100 °C 3: H2 / 5percent Pd/C View Scheme
参考文献
Boettcher, Henning; Gericke, Rolf
Liebigs Annalen der Chemie, 1988 , p. 749 - 752
反应条件
potassium permanganate in pyridine; water 72 h; Heating / reflux;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2004/7491 A1, 2004 ;
Location in patent: Page 56-57 ;
参考文献
Robertson; Beedle; Wilson; Parli; Smallwood; Steinberg
Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1290 - 1295
反应条件
sulfuric acid in ethanol T=20°C; (electrochemical reduction);
参考文献
le Guyader,M.
Bulletin de la Societe Chimique de France, 1966 , p. 1848 - 1858
反应条件
1.1: sulfuric acid / 16 h / |Reflux 2.1: palladium 10 on activated carbon; ammonium formate / methanol / 3 h / 20 °C / |Inert atmosphere 3.1: potassium acetate / toluene / 0.17 h / |Inert atmosphere; |Reflux 3.2: 16.5 h / |Reflux; |Inert atmosphere 4.1: lithium hydroxide hydrate / tetrahydrofuran; water / 48 h / |Reflux 4.2: pH 4 View Scheme
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
US 20120277224 A1
反应条件
1: 99 percent / borane-dimethyl sulfide complex / tetrahydrofuran / 18 h / 0 °C 2: 93 percent / Ph3P, CBr4 / CH2Cl2 / 18 h / 0 °C View Scheme
参考文献
Dhanoa, Daljit S.; Bagley, Scott W.; Chang, Raymond S. L.; Lotti, Victor J.; Chen, Tsing-Bau; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 26 p. 4239 - 4249
反应条件
1: PCl5 / Behandlung des entstandenen Chlorids mit konz. Ammoniak 2: aqueous ammonium sulfide View Scheme
参考文献
Beilstein; Kreusler
Justus Liebigs Annalen der Chemie, 1867 , vol. 144, p. 182
