bromine in chloroform T=20°C; 72 h;

1: With toluene-4-sulfonic acid in water; acetonitrile T=20°C; 0.0833333 h; 2: With N-bromosuccinmide in water; acetonitrile T=20°C; 2 h; regioselective reaction;

N-bromosuccinmide in acetonitrile T=20°C; 2 h; regioselective reaction;

暂无反应条件数据

potassium hydroxide T=60 - 80°C;

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 50 - 60 °C / |Large scale 2: water; N,N-dimethyl-formamide / 1 h / 70 °C / |Large scale 3: potassium carbonate; copper(l) chloride / N,N-dimethyl-formamide / 12 h / 100 °C / |Inert atmosphere; |Large scale View Scheme

potassium carbonate in N,N-dimethyl-formamide T=20°C; 4 h;

1: acetic acid; chlorine 2: aqueous KOH View Scheme