2-(溴甲基)吡啶 氢溴酸盐合成路线 （共 8 条）
反应条件
4 h; RefluxInert atmosphereSchlenk technique;
参考文献
Howson, Suzanne E.; Clarkson, Guy J.; Faulkner, Alan D.; Kaner, Rebecca A.; Whitmore, Michael J.; Scott, Peter
Dalton Transactions, 2013 , vol. 42, # 42 p. 14967 - 14981
反应条件
potassium carbonate in acetone T=25°C; 7 h;
参考文献
TOTAL PETROCHEMICALS RESEARCH FELUY
Patent: WO2008/61900 A1, 2008 ;
Location in patent: Page/Page column 8 ;
反应条件
1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C 2: trifluoroacetic acid / 0.25 h / 20 °C View Scheme
参考文献
Huang, Xiaohua; Shipps, Gerald W.; Cheng, Cliff C.; Spacciapoli, Peter; Zhang, Xingmin; McCoy, Mark A.; Wyss, Daniel F.; Yang, Xianshu; Achab, Abdelghani; Soucy, Kyle; Montavon, Donna K.; Murphy, Denise M.; Whitehurst, Charles E.
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 8 p. 632 - 637
反应条件
1: With potassium carbonate in acetonitrile T=10 - 20°C; 24 h; 2: With sodium tetrahydroborate in ethanol T=-10°C; 12 h;
参考文献
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE BOURGOGNE; Denat, Franck; Desogere, Pauline; Bernhard, Claire; Rousselin, Yoann; Boschetti, Frederic
Patent: US2014/142298 A1, 2014 ;
Location in patent: Paragraph 0297; 0298 ;
反应条件
triethylamine in acetonitrile T=55°C; 0.5 h;
参考文献
MOLECULAR INSIGHT PHARMACEUTICALS
Patent: WO2005/79865 A1, 2005 ;
Location in patent: Page/Page column 78-79 ;
反应条件
triethylamine in acetonitrile T=55°C; 0.5 h;
参考文献
Babich, John W.; Maresca, Kevin P.
Patent: US2003/235843 A1, 2003 ;
Location in patent: Page 21 ;
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C;
参考文献
Wheeler, William J.; Clodfelter, Dean K.
Journal of Labelled Compounds and Radiopharmaceuticals, 2008 , vol. 51, # 4 p. 175 - 181
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile T=20°C; 48 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2005/92856 A1, 2005 ;
Location in patent: Page/Page column 123 ;
WO 2005/092856 A1
