5-氟-1H-吲哚-3-羧酸甲酯合成路线 （共 9 条）
反应条件
1: 5-fluoro-1H-indole; N,N-dimethyl-formamide With trifluoroacetic anhydride T=0°C; 0.5 h; 2: With sodium hydroxide; water T=100°C; 1 h; 3: methanol With hydrogenchloride; sulfuric acid; water more than 3 stages;
参考文献
PIRAMED LIMITED; THE INSTITUTE OF CANCER RESEARCH
Patent: WO2008/125839 A2, 2008 ;
Location in patent: Page/Page column 21; 33-34 ;
WO 2008/125839 A2
反应条件
1: 5-fluoro-1H-indole; trifluoroacetic anhydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: With sodium hydroxide in water 1 h; Heating / reflux; 3: methanol With sulfuric acid T=65°C; 18 h; Heating / reflux;
参考文献
WO2008/152387 A1, ;
Page/Page column 27; 32 ;
WO 2008/152387 A1
反应条件
1: 5-fluoro-1H-indole With trifluoroacetic anhydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: With sodium hydroxide in water 1 h; Heating / reflux; 3: methanol With hydrogenchloride; sulfuric acid more than 3 stages;
参考文献
WO2009/53715 A1, ;
Page/Page column 60-61 ;
WO 2009/053715 A1
反应条件
sulfuric acid Heating / reflux;
参考文献
PIRAMED LIMITED
Patent: WO2007/122410 A1, 2007 ;
Location in patent: Page/Page column 73-74 ;
反应条件
pyridine; sodium hydroxide in 1,4-dioxane; methanol
参考文献
Astrazeneca AB
Patent: US6492406 B1, 2002 ;
US 6492406 B1
反应条件
copper diacetate; potassium carbonate; palladium dichloride in N,N-dimethyl-formamide T=120°C; 10 h;
参考文献
Ji, Xiaochen; Huang, Huawen; Wu, Wanqing; Li, Xianwei; Jiang, Huanfeng
Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11155 - 11162
反应条件
T=700°C; P=2.25023E-05 Torr; 2 h; Flash vacuum thermolysis (FVT);
参考文献
Australian Journal of Chemistry, , vol. 62, # 2 p. 115 - 120
反应条件
1: palladium diacetate; lithium bromide; oxygen / tetrahydrofuran / 8 h / 50 °C / |Schlenk technique 2: palladium dichloride; copper diacetate; potassium carbonate / N,N-dimethyl-formamide / 10 h / 120 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 22 p. 11155 - 11162
反应条件
T=500°C; P=2.25023E-05 Torr; 2 h; Flash vacuum thermolysis (FVT);
参考文献
Australian Journal of Chemistry, , vol. 62, # 2 p. 115 - 120
