2-(氯甲基)-6-甲基吡啶盐酸盐合成路线 （共 4 条）
反应条件
thionyl chloride T=0 - 20°C; 18 h;
参考文献
HANMI PHARM. CO., LTD.; BANG, Keuk Chan; PARK, Chang Hee; CHOI, Jae Yul; KIM, Seo Hee; HAM, Young Jin
Patent: WO2014/3483 A1, 2014 ;
Location in patent: Page/Page column 24 ;
参考文献
Baker et al.
Journal of the Chemical Society, 1958 , p. 3594,3601
反应条件
in ethanol; water 96 h; Ambient temperature;
参考文献
Zara-Kaczian, Erzsebet; Deak, Gyula; Gyoergy, Lajos
Acta Chimica Hungarica, 1989 , vol. 126, # 4 p. 441 - 454
反应条件
1: ethanol / Heating
2: aq. NaOH / 70 °C
3: aq. NaOH
4: t-BuOK / tetrahydrofuran; hexamethylphosphoric acid triamide / Ambient temperature
5: 1.) n-BuLi, diisopropylamine / 1.) hexane, THF, HMPA, -60 deg C, 2.) hexane, THF, HMPA, -60 deg C, 1 h
View Scheme
参考文献
Aloup, Jean-Claude; Bouchaudon, Jean; Farge, Daniel; James, Claude; Deregnaucourt, Jean; Hardy-Houis, Monique
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 24 - 29
