3,5-二甲基-4-氨基苯酚合成路线 （共 32 条）
反应条件
sodium acetate in water 1 h;
参考文献
Fernando; Calder; Ham
Journal of Medicinal Chemistry, 1980 , vol. 23, # 11 p. 1153 - 1158
反应条件
sodium carbonate in diethyl ether; water T=0°C; 0.416667 h;
参考文献
Fishbein, James C.; McClelland, Robert A.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1995 , # 4 p. 653 - 662
参考文献
Agfa
Patent: DE291499 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 13, p. 501
反应条件
1: 1.) FeCl3, aq. HCl; 2.) Na2S2O4 2: aq. NaOH 3: 39 percent / cc HCl / H2O / 60 °C View Scheme
参考文献
Togo, Hideo; Hashimoto, Kiichi; Morihashi, Kenji; Kikuchi, Osamu
Bulletin of the Chemical Society of Japan, 1988 , vol. 61, p. 3026 - 3028
反应条件
pyridine in ethyl acetate T=70°C; 1 h;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1403255 A1, 2004 ;
Location in patent: Page 170 ;
EP 1403255 A1
反应条件
potassium tert-butylate in N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
Micksch, Maik; Tenne, Mario; Strassner, Thomas
European Journal of Organic Chemistry, 2013 , # 27 p. 6137 - 6145
反应条件
1: aqueous solution; Fe2(SO4)3; steam 2: ethanolic sulfuric acid View Scheme
参考文献
Smith; Irwin
Journal of the American Chemical Society, 1941 , vol. 63, p. 1036,1040
反应条件
1: aqueous solution; Fe2(SO4)3; steam 2: ethanolic sulfuric acid 3: sodium dithionite; aqueous ethanol View Scheme
参考文献
Smith; Irwin
Journal of the American Chemical Society, 1941 , vol. 63, p. 1036,1040
反应条件
acetic acid; sodium nitrite
T=10 - 15°C; anschliessendes Erwaermen auf 90grad;
参考文献
Merck,E.
Patent: DE736797 , 1940 ;
DRP/DRBP Org.Chem.
反应条件
1: 89 percent / NaOAc / H2O / 1 h
2: 41 percent / Pb(OAc)4 / ethyl acetate / 45 °C
View Scheme
参考文献
Fernando; Calder; Ham
Journal of Medicinal Chemistry, 1980 , vol. 23, # 11 p. 1153 - 1158
