(2,5-二甲基苯基)溴化镁合成路线 （共 15 条）
反应条件
magnesium in tetrahydrofuran T=0°C;
参考文献
US2005/107305 A1, ;
Page/Page column 19 ;
反应条件
1: tetrahydrofuran / 24 h / -78 - 20 °C 2: 19.27 g / aq. HCl / tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Macromolecules, , vol. 36, # 4 p. 1009 - 1020
反应条件
1: With zinc(II) chloride in tetrahydrofuran T=-3 - 20°C; Inert atmosphere; 2: With N,N'-dimethyl-N,N'-propyleneurea; copper(l) iodide; tributylphosphine; acetone oxime-o-p-benzenesulfonic ester in tetrahydrofuran T=20°C; 1.5 h; Inert atmosphere; 3: With hydrogenchloride; water in tetrahydrofuran T=20°C; 4 h; Inert atmosphere;
参考文献
Daskapan, Tahir; Koca, Selcuk
Applied Organometallic Chemistry, 2010 , vol. 24, # 1 p. 12 - 16
反应条件
diethyl ether T=-60°C;
参考文献
Gattermann
Justus Liebigs Annalen der Chemie, 1912 , vol. 393, p. 224
参考文献
Smith; Stanfield
Journal of the American Chemical Society, 1949 , vol. 71, p. 81
反应条件
phosphorus trichoride in tetrahydrofuran 0 deg C then reflux, 2 h;
参考文献
Journal of Organic Chemistry, , vol. 56, # 11 p. 3537 - 3542
参考文献
Faber; Nauta
Recueil des Travaux Chimiques des Pays-Bas, 1942 , vol. 61, p. 469,471
Recueil des Travaux Chimiques des Pays-Bas, 1943 , vol. 62, p. 469,474, 477
反应条件
1: (i), (ii) oxalic acid, (dehydration)
2: (i) pentyl nitrite, aq. HCl, AcOH, (ii) Py
3: aq. H2SO4 / Heating
4: (i) KOtBu, (ii) aq. HCl, AcOH, (heating), (iii) (decarboxylation)
5: KOH, N2H4*H2O / bis-(2-hydroxy-ethyl) ether / Heating
6: HF
7: (i) KOH, N2H4*H2O, (heating), (ii) Pd-C, (heating)
View Scheme
参考文献
Bien,S. et al.
Journal of the Chemical Society, 1965 , p. 1495 - 1498
反应条件
1: diethyl ether / 6 h
2: H2, 70percent HClO4 / 10percent Pd/C / methanol / 15 h / 2250.2 Torr / Ambient temperature
View Scheme
参考文献
Shapiro, Israel O.; Nir, Malka; Hoffman, Roy E.; Rabinovitz, Mordecai
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1994 , # 7 p. 1519 - 1524
参考文献
Papa; Perlman; Bogert
Journal of the American Chemical Society, 1938 , vol. 60, p. 319
