5,6-二甲基-1H-吲哚合成路线 （共 8 条）
反应条件
manganese(IV) oxide; 4 A molecular sieve in benzene T=40 - 50°C; 2 h;
参考文献
Chandra, Tilak; Zou, Shawn; Brown, Kenneth L.
Tetrahedron Letters, 2004 , vol. 45, # 41 p. 7783 - 7786
反应条件
nitrogen in N,N-dimethyl-formamide
参考文献
Hoffmann-La Roche Inc.
Patent: US3976639 A1, 1976 ;
反应条件
potassium tert-butylate T=270 - 280°C;
参考文献
Brown, Kenneth L.; Chandra, Tilak; Zou, Shawn; Valente, Edward J.
Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 8 p. 1147 - 1165
反应条件
1: 60 percent / NaHCO3 / aq. ethanol / 96 h / Heating 2: 2) KOH / 1) CF3COOH, 0 deg C, 30 min, then reflux 70 h; 2) MeOH, room temperature View Scheme
参考文献
Nordlander, J. Eric; Catalane, David B.; Kotian, Kirtivan D.; Stevens, Randall M.; Haky, Jerome E.
Journal of Organic Chemistry, 1981 , vol. 46, p. 778 - 782
反应条件
1: 95 percent / triethylamine / hexane / ice-water bath, then room temperature, 1 h 2: 1) 30 percent (CF3CO)2O; 2) KOH / 1) CF3COOH, 56 deg C, 75 h; 2) MeOH, room temperature View Scheme
参考文献
Nordlander, J. Eric; Catalane, David B.; Kotian, Kirtivan D.; Stevens, Randall M.; Haky, Jerome E.
Journal of Organic Chemistry, 1981 , vol. 46, p. 778 - 782
反应条件
potassium hydroxide; trifluoroacetic anhydride 1) CF3COOH, 56 deg C, 75 h; 2) MeOH, room temperature; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Nordlander, J. Eric; Catalane, David B.; Kotian, Kirtivan D.; Stevens, Randall M.; Haky, Jerome E.
Journal of Organic Chemistry, 1981 , vol. 46, p. 778 - 782
反应条件
potassium hydroxide 1) CF3COOH, 0 deg C, 30 min, then reflux 70 h; 2) MeOH, room temperature; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Nordlander, J. Eric; Catalane, David B.; Kotian, Kirtivan D.; Stevens, Randall M.; Haky, Jerome E.
Journal of Organic Chemistry, 1981 , vol. 46, p. 778 - 782
反应条件
sodium cyanoborohydride in acetic acid
T=12°C; 2 h;
参考文献
Chandra, Tilak; Brown, Kenneth L.
Tetrahedron Letters, 2005 , vol. 46, # 12 p. 2071 - 2074
