(2S)-2-[[4-[二(2-氯乙基)氨基]苯甲酰基]氨基]戊烷二酸合成路线 （共 7 条）
反应条件
1: Et3N / CH2Cl2 2: H2 / 10percent Pd/C 3: 78 percent / acetic acid / 48 h / Ambient temperature 4: 77 percent / pyridine / 1.) 2 deg C, 20 min, 2.) 80 deg C, 80 min 5: 94 percent / trifluoroacetic acid / 0.5 h / Ambient temperature View Scheme
参考文献
Springer, Caroline J.; Antoniw, Pari; Bagshawe, Kenneth D.; Searle, Frances; Bisset, Graham M. F.; Jarman, Michael
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 677 - 681
反应条件
1: H2 / 10percent Pd/C 2: 78 percent / acetic acid / 48 h / Ambient temperature 3: 77 percent / pyridine / 1.) 2 deg C, 20 min, 2.) 80 deg C, 80 min 4: 94 percent / trifluoroacetic acid / 0.5 h / Ambient temperature View Scheme
参考文献
Springer, Caroline J.; Antoniw, Pari; Bagshawe, Kenneth D.; Searle, Frances; Bisset, Graham M. F.; Jarman, Michael
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 677 - 681
反应条件
1: 78 percent / acetic acid / 48 h / Ambient temperature 2: 77 percent / pyridine / 1.) 2 deg C, 20 min, 2.) 80 deg C, 80 min 3: 94 percent / trifluoroacetic acid / 0.5 h / Ambient temperature View Scheme
参考文献
Springer, Caroline J.; Antoniw, Pari; Bagshawe, Kenneth D.; Searle, Frances; Bisset, Graham M. F.; Jarman, Michael
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 677 - 681
反应条件
1: 77 percent / pyridine / 1.) 2 deg C, 20 min, 2.) 80 deg C, 80 min 2: 94 percent / trifluoroacetic acid / 0.5 h / Ambient temperature View Scheme
参考文献
Springer, Caroline J.; Antoniw, Pari; Bagshawe, Kenneth D.; Searle, Frances; Bisset, Graham M. F.; Jarman, Michael
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 677 - 681
反应条件
T=37°C; 3 h; bacterial carboxypeptidase enzyme (CPG2), pH 7.4; Rate constant;
参考文献
Dowell, Robert I.; Springer, Caroline J.; Davies, David H.; Hadley, Elizabeth M.; Burke, Philip J.; Boyle, F. Thomas; Melton, Roger G.; Connors, Thomas A.; Blakey, David C.; Mauger, Anthony B.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1100 - 1105
反应条件
bacterial enzyme carboxypeptidase (CPG2)
参考文献
Springer, Caroline J.; Antoniw, Pari; Bagshawe, Kenneth D.; Searle, Frances; Bisset, Graham M. F.; Jarman, Michael
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 677 - 681
反应条件
T=37°C; 3 h; bacterial carboxypeptidase enzyme (CPG2), pH 7.4; Rate constant;
参考文献
Dowell, Robert I.; Springer, Caroline J.; Davies, David H.; Hadley, Elizabeth M.; Burke, Philip J.; Boyle, F. Thomas; Melton, Roger G.; Connors, Thomas A.; Blakey, David C.; Mauger, Anthony B.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1100 - 1105
