2-甲基-吡唑并[1,5-a]吡啶-3-羧酸乙酯合成路线 （共 3 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 72 h;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.; TAKEDA PHARMACEUTICAL COMPANY LIMITED; BANNO, Hiroshi; HIROSE, Masaaki; KURASAWA, Osamu; LANGSTON, Steven, P.; MIZUTANI, Hirotake; SHI, Zhan; VISIERS, Irache; VOS, Tricia, J.; VYSKOCIL, Stepan
Patent: WO2010/90716 A1, 2010 ;
Location in patent: Page/Page column 269 ;
参考文献
Asahi Kasei Kogyo Kabushiki Kaisha
Patent: US5200415 A1, 1993 ;
反应条件
sodium hydroxide
1) water, 30 min, reflux, 2) 95percent ethanol, 20 min, reflux, 3) HCl;
参考文献
Anderson, Paul L.; Hasak, James P; Kahle, Alicia D.; Paolella, Nicholas A.; Shapiro, Michael J.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1149 - 1152
