2,4,6-三溴-3,5-二氟吡啶合成路线 （共 7 条）
反应条件
aluminum tri-bromide; hydrogen bromide T=150°C; 84 h;
参考文献
Benmansour; Chambers; Hoskin; Sandford
Journal of Fluorine Chemistry, 2001 , vol. 112, # 1 p. 133 - 137
反应条件
in sulfolane C5F5N, dissolved in sulfolane, reacts with HBr at 100 °C (20 h), then at 130-160 °C (148 h).;
参考文献
Journal of the Chemical Society [Section] C: Organic, , p. 61 - 67
反应条件
hydrogen; triethylamine; palladium on activated charcoal in dichloromethane P=3000.2 Torr; 21 h; Ambient temperature;
参考文献
Chambers, Richard D.; Hall, Christopher W.; Hutchinson, John; Millar, Ross W.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 10 p. 1705 - 1713
反应条件
1: 63 percent / H2, Et3N / Pd/C / CH2Cl2 / 21 h / 3000.2 Torr / Ambient temperature 2: 71 percent / peracetic acid / CHCl3; acetic acid / 24 h / 50 °C View Scheme
参考文献
Chambers, Richard D.; Hall, Christopher W.; Hutchinson, John; Millar, Ross W.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 10 p. 1705 - 1713
反应条件
1: 93 percent / NH3 / acetonitrile; H2O / 72 h / 75 °C 2: H2, Et3N / Pd/C / CH2Cl2 / 18 h / 3000.2 Torr / Ambient temperature View Scheme
参考文献
Chambers, Richard D.; Hall, Christopher W.; Hutchinson, John; Millar, Ross W.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 10 p. 1705 - 1713
反应条件
barium dihydroxide; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water T=90°C; Suzuki cross-coupling reaction; 48 h;
参考文献
Benmansour, Hadjar; Chambers, Richard D.; Sandford, Graham; Batsanov, Andrei S.; Howard, Judith A.K.
Journal of Fluorine Chemistry, 2007 , vol. 128, # 7 p. 718 - 722
反应条件
copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride 88 h; Ambient temperature; Yields of byproduct given;
参考文献
Chambers, Richard D.; Hall, Christopher W.; Hutchinson, John; Millar, Ross W.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 10 p. 1705 - 1713
