(2S)-2-氨基-3-苯丙酸乙酯合成路线 （共 35 条）
反应条件
1.1: sodium hydrogencarbonate / tetrahydrofuran; methanol / 60 h 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 60 h / 20 °C / Cooling with ice 2.2: 0.58 h / 0 - 20 °C View Scheme
参考文献
GLAXOSMITHKLINE LLC; JOHNS, Brian Alvin; TEMELKOFF, David P.; VELTHUISEN, Emile Johann; WEATHERHEAD, Jason Gordon
Patent: WO2011/17395 A1, 2011 ;
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C 2: silver(l) oxide / N,N-dimethyl-formamide / 20 °C 3: hydrogenchloride; water / methanol / 2 h / 20 °C View Scheme
参考文献
Molinski, Tadeusz F.; Reynolds, Kirk A.; Morinaka, Brandon I.
Journal of Natural Products, 2012 , vol. 75, # 3 p. 425 - 431
反应条件
1: NaHCO3 / sonification 2: DIBAL-H / CH2Cl2 / -78 °C View Scheme
参考文献
Synlett, , # 3 p. 435 - 439
反应条件
diethyl ether; potassium hydrogencarbonate Behandeln des Reaktionsprodukts mit wss.-aethanol. Natronlauge;
参考文献
Hofmann; Bergmann
Journal of Biological Chemistry, 1940 , vol. 134, p. 225,233
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Neurath; Elkins; Kaufman
Journal of Biological Chemistry, 1947 , vol. 170, p. 221,222
反应条件
hydroxylamine in dimethyl sulfoxide T=40°C; 1 h; protease I of Streptomyces griseus in 0.1 M phosphate buffer; other conc. of DMSO and NH2OH, different times: Activation of transfer reaction by organic solvents; Kinetics;
参考文献
Bernardo, Marisa; Pacheco, Rita; Serralheiro, Maria Luisa M.; Karmali, Amin
Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 93, p. 28 - 33
反应条件
1: diethyl ether 2: acetone; aqueous NaOH 3: palladium; acetic acid; methanol / Hydrogenation View Scheme
参考文献
Smith et al.
Journal of Biological Chemistry, 1952 , vol. 199, p. 801,808
参考文献
Feenstra, R. W.; Stokkingreef, E. H. M.; Reichwein, A. M.; Lousberg, W. B. H.; Ottenheijm, H. C. J.; et al.
Tetrahedron, 1990 , vol. 46, # 5 p. 1745 - 1756
反应条件
(1-methyl-3-(3-sulfopropyl)-1H-imidazol-3-ium)3[PW12O403-] in neat (no solvent) T=100°C; 0.116667 h; Green chemistry; Overall yield = 87 percent;
参考文献
Chen, Zhikai; Fu, Renzhong; Chai, Wen; Zheng, Hao; Sun, Lin; Lu, Qiang; Yuan, Rongxin
Tetrahedron, 2014 , vol. 70, # 13 p. 2237 - 2245
反应条件
1: diethyl ether / 2 h / Ambient temperature 2: Zn-Cu couples / tetrahydrofuran / 1 h / Heating 3: Jones'reagent (CrO3-H2SO4) / acetone View Scheme
参考文献
Matsuo; Kitaguchi; Takata; Tanaka
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 8 p. 2494 - 2502
反应条件
in dichloromethane T=20°C;
参考文献
Smallridge, Andrew J.; Trewhella, Maurie A.; Wang
Australian Journal of Chemistry, 2002 , vol. 55, # 4 p. 259 - 262
