1-乙酰氧基-2,3,5-三苯甲酰氧基-β-L-呋喃核糖合成路线 （共 41 条）
反应条件
1: sulfuric acid / 5 h / 20 °C 2: pyridine / 20 °C / Cooling with ice 3: sulfuric acid; acetic acid / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 23 p. 7100 - 7110
反应条件
1: pyridine / 20 °C / Cooling with ice 2: sulfuric acid; acetic acid / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 23 p. 7100 - 7110
反应条件
acetic anhydride; acetic acid; zinc(II) chloride in dichloromethane-d2 T=25°C; Kinetics; TimeConcentrationReagent/catalyst;
参考文献
Carbohydrate Research, , vol. 344, # 9 p. 1102 - 1109
反应条件
1: 98 percent / BSA; TMSOTf / acetonitrile / 65 °C 2: 97 percent / NaOMe / methanol / 20 °C 3: 82 percent / DMAP / pyridine / 20 °C 4: 88 percent / DMAP / acetonitrile / 20 °C 5: 82 percent / AIBN; Bu3SnH / toluene / 80 - 90 °C 6: 75 percent / Bu4NF / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Moyroud; Botta; Strazewski
Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 693 - 695
反应条件
ammonia; sodium hydrogencarbonate; tin(IV) chloride in methanol; water; ethyl acetate; acetonitrile
参考文献
Novirio Pharmaceuticals Limited; Centre National da la Recherche Scientifique
Patent: US6444652 B1, 2002 ;
Title/Abstract Full Text Show Details
Novirio Pharmaceuticals Limited; Centre National da la Recherche Scientifique
Patent: US6395716 B1, 2002 ;
反应条件
benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate in acetonitrile T=65°C; Condensation;
参考文献
Moyroud, Elisabeth; Biala, Ewa; Strazewski, Peter
Tetrahedron, 2000 , vol. 56, # 11 p. 1475 - 1484
反应条件
1: 98 percent / BSA; TMSOTf / acetonitrile / 65 °C 2: 97 percent / NaOMe / methanol / 20 °C 3: 82 percent / DMAP / pyridine / 20 °C 4: 88 percent / DMAP / acetonitrile / 20 °C 5: 82 percent / AIBN; Bu3SnH / toluene / 80 - 90 °C 6: 75 percent / Bu4NF / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Moyroud; Botta; Strazewski
Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 693 - 695
反应条件
hydrogenchloride; water; acetyl chloride 1.) CH2Cl2, 0 deg C, 2.) CH3CN; Yield given. Multistep reaction;
参考文献
NOVADEX PHARMACEUTICALS AB; ZHOU, Xiao Xiong; TORSSELL, Staffan; WALLNER, Olov; SUN, Piaoyang
Patent: WO2011/75052 A1, 2011 ;
Location in patent: Page/Page column 49 ;
反应条件
1: 1.) HCl gas, AcCl, 2.) H2O / 1.) CH2Cl2, 0 deg C, 12 h, 2.) MeCN, 0 deg C, 30 min 2: 1.) SO2Cl2 / 1.) CH2Cl2, DMF, room temperature, 3 h, 2.) room temperature, 20 h 3: 1.) Et3N*3HF, 2.) Et3N / 1.) EtOAc, 80 deg C, 3 h, 2.) 80 deg C, 1 h View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 18, # 2 p. 187 - 195
反应条件
1: 98 percent / BSA; TMSOTf / acetonitrile / 65 °C 2: 97 percent / NaOMe / methanol / 20 °C View Scheme
参考文献
Moyroud, Elisabeth; Biala, Ewa; Strazewski, Peter
Tetrahedron, 2000 , vol. 56, # 11 p. 1475 - 1484
