2-(4-氧代-1H-喹唑啉-2-基)乙腈合成路线 （共 12 条）
反应条件
triethylamine in ethanol 6 h; Heating;
参考文献
Aziz, M. A. Abdel; Daboun, H. A.; Gawad, S. M. Abdel
Journal fuer Praktische Chemie (Leipzig), 1990 , vol. 332, # 5 p. 610 - 618
反应条件
pyrrolidine in isopropyl alcohol Heating;
参考文献
Khilya; Baglay; Volovenko
Chemistry of Heterocyclic Compounds, 2010 , vol. 46, # 8 p. 934 - 937
反应条件
montmorillonite K-10 T=150°C; 2 h;
参考文献
Roopan, S. Mohana; Maiyalagan; Khan, F. Nawaz
Canadian Journal of Chemistry, 2008 , vol. 86, # 11 p. 1019 - 1025
反应条件
in methanol Heating;
参考文献
Volovenko; Khilya; Volovnenko; Shokol
Chemistry of Heterocyclic Compounds, 2002 , vol. 38, # 3 p. 314 - 323
反应条件
in water; N,N-dimethyl-formamide T=80°C; 4 h; Inert atmosphere;
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
参考文献
Essawy, A.; El-Hashash, M. A.; Mohamed, M. M.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 8 p. 663 - 666
反应条件
1: pyridine / N,N-dimethyl-formamide 2: potassium carbonate; urea hydrogen peroxide addition compound / acetone; water 3: hydrogen bromide / water 4: triphenylphosphine; carbon tetrabromide / dichloromethane / 22 h / 0 - 20 °C 5: water; N,N-dimethyl-formamide / 4 h / 80 °C / |Inert atmosphere View Scheme
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
反应条件
1: potassium carbonate; urea hydrogen peroxide addition compound / acetone; water 2: hydrogen bromide / water 3: triphenylphosphine; carbon tetrabromide / dichloromethane / 22 h / 0 - 20 °C 4: water; N,N-dimethyl-formamide / 4 h / 80 °C / |Inert atmosphere View Scheme
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
反应条件
1: hydrogen bromide / water 2: triphenylphosphine; carbon tetrabromide / dichloromethane / 22 h / 0 - 20 °C 3: water; N,N-dimethyl-formamide / 4 h / 80 °C / |Inert atmosphere View Scheme
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
反应条件
1: triphenylphosphine; carbon tetrabromide / dichloromethane / 22 h / 0 - 20 °C 2: water; N,N-dimethyl-formamide / 4 h / 80 °C / |Inert atmosphere View Scheme
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
