4,5,6,7-四氢吡唑并[1,5-a]吡啶-2-甲酰氯合成路线 （共 4 条）
反应条件
oxalyl dichloride in toluene T=20 - 60°C; 4.5 h;
参考文献
Duvey, Guillaume; Perry, Benjamin; Le Poul, Emmanuel; Poli, Sonia; Bonnet, Beatrice; Lambeng, Nathalie; Charvin, Delphine; Donovan-Rodrigues, Tansy; Haddouk, Hasnaa; Gagliardi, Stefania; Rocher, Jean-Philippe
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 16 p. 4523 - 4527
反应条件
1.1: sodium nitrite; hydrogenchloride / 0 °C 1.2: 20 °C 2.1: anhydrous xylene / |Reflux 3.1: methanol; potassium hydroxide / 20 °C 4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C View Scheme
参考文献
Duvey, Guillaume; Perry, Benjamin; Le Poul, Emmanuel; Poli, Sonia; Bonnet, Beatrice; Lambeng, Nathalie; Charvin, Delphine; Donovan-Rodrigues, Tansy; Haddouk, Hasnaa; Gagliardi, Stefania; Rocher, Jean-Philippe
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 16 p. 4523 - 4527
反应条件
1: anhydrous xylene / |Reflux 2: methanol; potassium hydroxide / 20 °C 3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C View Scheme
参考文献
Duvey, Guillaume; Perry, Benjamin; Le Poul, Emmanuel; Poli, Sonia; Bonnet, Beatrice; Lambeng, Nathalie; Charvin, Delphine; Donovan-Rodrigues, Tansy; Haddouk, Hasnaa; Gagliardi, Stefania; Rocher, Jean-Philippe
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 16 p. 4523 - 4527
反应条件
1: methanol; potassium hydroxide / 20 °C 2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C View Scheme
参考文献
Duvey, Guillaume; Perry, Benjamin; Le Poul, Emmanuel; Poli, Sonia; Bonnet, Beatrice; Lambeng, Nathalie; Charvin, Delphine; Donovan-Rodrigues, Tansy; Haddouk, Hasnaa; Gagliardi, Stefania; Rocher, Jean-Philippe
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 16 p. 4523 - 4527
