4,5,6,7-四氢吡唑并[1,5-a]吡啶-2-羧酸合成路线 （共 7 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=80°C; P=12001.2 Torr; 4 h;
参考文献
SCHWARZ PHARMA AG
Patent: WO2006/15737 A1, 2006 ;
Location in patent: Page/Page column 49 ;
反应条件
sodium hydroxide in 1,4-dioxane; water T=20°C;
参考文献
EP1241170 A2, ;
Page 59 ;
EP 1241170 A2
反应条件
methanol; potassium hydroxide T=20°C;
参考文献
Duvey, Guillaume; Perry, Benjamin; Le Poul, Emmanuel; Poli, Sonia; Bonnet, Beatrice; Lambeng, Nathalie; Charvin, Delphine; Donovan-Rodrigues, Tansy; Haddouk, Hasnaa; Gagliardi, Stefania; Rocher, Jean-Philippe
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 16 p. 4523 - 4527
反应条件
1: anhydrous xylene / 2 h / Reflux 2: sodium hydroxide / 1,4-dioxane / 18 h / 20 - 25 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 1 p. 498 - 509
反应条件
1.1: hydrogenchloride; sodium nitrite / water / 0 °C / Cooling with acetone-dry ice 1.2: 19 h / 20 - 25 °C / Cooling with ice 2.1: anhydrous xylene / 2 h / Reflux 3.1: sodium hydroxide / 1,4-dioxane / 18 h / 20 - 25 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 1 p. 498 - 509
反应条件
1: trifluoroacetic anhydride 2: anhydrous xylene / Reflux 3: ethanol; sodium hydroxide View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 5 p. 1870 - 1873
反应条件
oxalyl dichloride in toluene T=20 - 60°C; 4.5 h;
参考文献
Duvey, Guillaume; Perry, Benjamin; Le Poul, Emmanuel; Poli, Sonia; Bonnet, Beatrice; Lambeng, Nathalie; Charvin, Delphine; Donovan-Rodrigues, Tansy; Haddouk, Hasnaa; Gagliardi, Stefania; Rocher, Jean-Philippe
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 16 p. 4523 - 4527
