5'-脱氧-5'-碘-2',3'-O-异亚丙基腺苷合成路线 （共 7 条）
反应条件
hydrogen; Ra-Ni in methanol 6 h;
参考文献
MacCoss, Malcolm; Ryu, Eung K.; White, Robert S.; Last, Robert L.
Journal of Organic Chemistry, 1980 , vol. 45, # 5 p. 788 - 794
反应条件
PS-Ph3P; iodine in pyridine T=50°C;
参考文献
Perrone, Plinio; Daverio, Felice; Valente, Rocco; Rajyaguru, Sonal; Martin, Joseph A.; Leveque, Vincent; Le Pogam, Sophie; Najera, Isabel; Klumpp, Klaus; Smith, David B.; McGuigan, Christopher
Journal of Medicinal Chemistry, 2007 , vol. 50, # 22 p. 5463 - 5470
反应条件
methyltriphenoxy-phosphonium iodide in dichloromethane 2 h; Ambient temperature;
参考文献
Maguire, Anita R.; Meng, Wei-dong; Roberts, Stanley M.; Willetts, Andrew J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 15 p. 1795 - 1808
反应条件
1: 82 percent / NaI / acetone / 2.5 h / 80 - 85 °C 2: 56 percent / Si2Cl6 / CH2Cl2 / 0.75 h View Scheme
参考文献
MacCoss, Malcolm; Ryu, Eung K.; White, Robert S.; Last, Robert L.
Journal of Organic Chemistry, 1980 , vol. 45, # 5 p. 788 - 794
反应条件
1: 74 percent / methyltriphenoxyphosphonium iodide / dimethylformamide / 24 h / Ambient temperature 2: 56 percent / Si2Cl6 / CH2Cl2 / 0.75 h View Scheme
参考文献
MacCoss, Malcolm; Ryu, Eung K.; White, Robert S.; Last, Robert L.
Journal of Organic Chemistry, 1980 , vol. 45, # 5 p. 788 - 794
反应条件
1: 81 percent / m-chloroperbenzoic acid / various solvent(s) / 24 h / 2 - 3 °C 2: 82 percent / NaI / acetone / 2.5 h / 80 - 85 °C 3: 56 percent / Si2Cl6 / CH2Cl2 / 0.75 h View Scheme
参考文献
MacCoss, Malcolm; Ryu, Eung K.; White, Robert S.; Last, Robert L.
Journal of Organic Chemistry, 1980 , vol. 45, # 5 p. 788 - 794
反应条件
formic acid 19 h; Ambient temperature;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 15 p. 1795 - 1808
