2,3,4-三-O-乙酰基-α-D-木吡喃糖苷溴合成路线 （共 37 条）
反应条件
1: 30 percent / Ag2O / acetonitrile / 0.5 h / Ambient temperature
2: MeONa / methanol / 2 h / Ambient temperature
View Scheme
参考文献
Bellamy, Francois; Horton, Derek; Millet, Jean; Picart, Francois; Samreth, Soth; Chazan, Jean Bernard
Journal of Medicinal Chemistry, 1993 , vol. 36, # 7 p. 898 - 903
反应条件
1: 85 percent / Ag2O / acetonitrile / 0.5 h / Ambient temperature
2: MeONa / methanol / 2 h / Ambient temperature
View Scheme
参考文献
Bellamy, Francois; Horton, Derek; Millet, Jean; Picart, Francois; Samreth, Soth; Chazan, Jean Bernard
Journal of Medicinal Chemistry, 1993 , vol. 36, # 7 p. 898 - 903
反应条件
1: CuSO4‵5H2O; acetic acid; zinc / water / 2.5 h / 0 °C
2: methanol; sodium methylate / 4 h / 20 °C
3: dipyridinium dichromate; acetic acid / ethyl acetate / 16 h / 20 °C
4: caesium carbonate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
5: Oxonereg;; C8H6O4(2-)*Cu(2+) / toluene / 6 h / 60 °C / Molecular sieve; Air atmosphere
6: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane
7: toluene-4-sulfonic acid / toluene / 1 h / Reflux
View Scheme
参考文献
Matsuo, Kazumasa; Shindo, Mitsuru
Tetrahedron, 2011 , vol. 67, # 5 p. 971 - 975
反应条件
1: CuSO4‵5H2O; acetic acid; zinc / water / 2.5 h / 0 °C
2: methanol; sodium methylate / 4 h / 20 °C
3: dipyridinium dichromate; acetic acid / ethyl acetate / 16 h / 20 °C
4: Oxonereg;; C8H6O4(2-)*Cu(2+) / toluene / 7 h / 60 °C / Molecular sieve; Air atmosphere
5: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane / Reflux
View Scheme
参考文献
Matsuo, Kazumasa; Shindo, Mitsuru
Tetrahedron, 2011 , vol. 67, # 5 p. 971 - 975
反应条件
sodium azide in water; acetone
Substitution;
参考文献
Ibatullin, Farid M.; Shabalin, Konstantin A.
Synthetic Communications, 2000 , vol. 30, # 15 p. 2819 - 2823
参考文献
Bertho
Justus Liebigs Annalen der Chemie, 1949 , vol. 562, p. 229,237
反应条件
potassium hydroxide; chloroform
参考文献
Koehler; Hudson
Journal of the American Chemical Society, 1950 , vol. 72, p. 981
