L-天冬氨酸-4-叔丁基酯合成路线 （共 26 条）
反应条件
1: 78 percent / NaHCO3 / H2O; acetone / Ambient temperature 2: dicyclohexylcarbodiimide / ethyl acetate / 2 h / 0 °C View Scheme
参考文献
Schoen, Istvan; Kisfaludy, Lajos
Synthesis, 1986 , # 4 p. 303 - 305
反应条件
1: L-aspartic acid β-t-butyl ester With N,N-dicyclohexylamine in acetone T=20°C; 2: 1-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]-2,5-pyrrolidinedione With sodium carbonate in water; acetonitrile T=0 - 20°C; pH=8; 3: With potassium hydrogensulfate in water; acetonitrile pH=2 - 3;
参考文献
Nowshuddin, Shaik; Rao; Reddy, A. Ram
Synthetic Communications, 2009 , vol. 39, # 11 p. 2022 - 2031
反应条件
sodium hydrogencarbonate in water; acetone Ambient temperature;
参考文献
Schoen, Istvan; Kisfaludy, Lajos
Synthesis, 1986 , # 4 p. 303 - 305
反应条件
tertiary amine in 1,4-dioxane; water 3 h;
参考文献
Henklein, Peter; Heyne, Hans-Ulrich; Halatsch, Wolf-Rainer; Niedrich, Hartmut
Synthesis, 1987 , # 2 p. 166 - 167
反应条件
triethylamine in water; acetonitrile 1 h;
参考文献
Echner, Hartmut; Voelter, Wolfgang
Liebigs Annalen der Chemie, 1988 , p. 1095 - 1098
反应条件
in tetrahydrofuran T=20°C; 16 h;
参考文献
Goode, David R.; Sharma, Anil K.; Hergenrother, Paul J.
Organic Letters, 2005 , vol. 7, # 16 p. 3529 - 3532
反应条件
triethylamine in water; N,N-dimethyl-formamide T=20°C; 24 h;
参考文献
Piotrovskii, L. B.; Dumpis, M. A.; Poznyakova, L. N.; Aleksandrova, L. N.; Sepetov, N. F.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, p. 96 - 100
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 1 p. 111 - 116
反应条件
imidazole-1-sulfonyl azide hydrochloride; CuSO4‵5H2O; potassium carbonate in methanol T=20°C; 18 h;
参考文献
Valverde, Ibai E.; Lecaille, Fabien; Lalmanach, Gilles; Aucagne, Vincent; Delmas, Agnes F.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 3 p. 718 - 722
反应条件
1.1: tetrahydrofuran; water / 0.08 h / 0 °C 1.2: 24 h / 20 °C 2.1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / -30 °C 2.2: -30 - -10 °C 3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 2.17 h / -30 - 20 °C View Scheme
参考文献
Henry, Luc; Leung, Ivanhoe K.H.; Claridge, Timothy D.W.; Schofield, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 4975 - 4978
反应条件
triethylamine in 1,4-dioxane; water
参考文献
Centre National de la Recherche Scientifique(CNRS)
Patent: US2010/16631 A1, 2010 ;
Location in patent: Page/Page column 5-6 ;
