反应条件
1: 1) lithium hexamethyldisilazide / 1) THF, -78 deg C, 1h, 2) room temperature, 30 min 2: tetrahydrofuran / -78 °C 3: DIBAL-H / toluene / 2 h / -78 °C 4: 96 percent / pyridine, DMAP / CH2Cl2 / 2 h / 0 °C 5: 1) hexamethyldisilazane (HMDS), ammonium sulfate, 2) trimethylsilyl triflate (TMSOTf) / 1) reflux, 2 h, 2) 1,2-dichloroethane, a) 5 deg C, 10 min, b) room temperature, 10 min 6: 76 percent / 30percent aq. H2O2, pyridine / CH2Cl2 / 0.5 h / Ambient temperature 7: 78 percent / TBAF / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 14 p. 3887 - 3894
