5-甲氧基-3,4-二氢-1H-喹啉-2-酮合成路线 （共 5 条）
反应条件
hydrogenchloride T=90°C; 1 h;
参考文献
Tamura, Yasumitsu; Chen, Ling Ching; Fujita, Masanobu; Kita, Yasuyuki
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 4 p. 1257 - 1262
反应条件
1: 1.) Et3N; 2.) n-BuLi / 1.) hexane, tetrahydrofuran, 0 deg C, 2 h; 2.) dimethylformamide, 0 deg C, 1 h; room temp., 8 h 2: 77 percent / benzene / 2 h / Ambient temperature 3: 89 percent / H2 / 5 percent Pd-C / ethanol / 1 h / 3040 Torr / Ambient temperature 4: 43 percent / 10 percent aq.hydrochloric acid / 1 h / 90 °C View Scheme
参考文献
Tamura, Yasumitsu; Chen, Ling Ching; Fujita, Masanobu; Kita, Yasuyuki
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 4 p. 1257 - 1262
反应条件
1: 77 percent / benzene / 2 h / Ambient temperature 2: 89 percent / H2 / 5 percent Pd-C / ethanol / 1 h / 3040 Torr / Ambient temperature 3: 43 percent / 10 percent aq.hydrochloric acid / 1 h / 90 °C View Scheme
参考文献
Tamura, Yasumitsu; Chen, Ling Ching; Fujita, Masanobu; Kita, Yasuyuki
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 4 p. 1257 - 1262
反应条件
1: 89 percent / H2 / 5 percent Pd-C / ethanol / 1 h / 3040 Torr / Ambient temperature 2: 43 percent / 10 percent aq.hydrochloric acid / 1 h / 90 °C View Scheme
参考文献
Tamura, Yasumitsu; Chen, Ling Ching; Fujita, Masanobu; Kita, Yasuyuki
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 4 p. 1257 - 1262
反应条件
hydrogen bromide in water T=130°C; 2.5 h; Inert atmosphere;
参考文献
Bromidge, Steven M.; Arban, Roberto; Bertani, Barbara; Borriello, Manuela; Capelli, Anna-Maria; Di-Fabio, Romano; Faedo, Stefania; Gianotti, Massimo; Gordon, Laurie J.; Granci, Enrica; Pasquarello, Alessandra; Spada, Simone K.; Worby, Angela; Zonzini, Laura; Zucchelli, Valeria
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 23 p. 7092 - 7096
