2-氧代-1,5-戊二酸二钠盐二水合物合成路线 （共 7 条）
反应条件
in N-methyl-acetamide
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4891427 A1, 1990 ;
反应条件
thiamine pyrophosphate; α-ketoglutarate dehydrogenase; magnesium chloride in water T=30°C; 2 h; 0.05M KH2PO4 buffer (pH 7.5); Further byproducts given. Yields of byproduct given;
参考文献
Corbett, Michael D.; Corbett, Bernadette R.; Doerge, Daniel R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 345 - 350
反应条件
thiamine pyrophosphate; α-ketoglutarate dehydrogenase; magnesium chloride in water T=30°C; 2 h; 0.05M KH2PO4 buffer (pH 7.5); Further byproducts given. Yields of byproduct given;
参考文献
Corbett, Michael D.; Corbett, Bernadette R.; Doerge, Daniel R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 345 - 350
反应条件
thiamine pyrophosphate; α-ketoglutarate dehydrogenase; magnesium chloride in water T=30°C; 2 h; 0.05M KH2PO4 buffer (pH 7.5); Further byproducts given. Yields of byproduct given;
参考文献
Corbett, Michael D.; Corbett, Bernadette R.; Doerge, Daniel R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 345 - 350
反应条件
1: NaBH4; HCl / 0.08 h
2: NaHCO3 / aq. NaOH; acetonitrile / 20 °C / pH 7 - 8
View Scheme
参考文献
Ciceri, Daniele; Pierik, Antonio J.; Hartrampf, Guenter; Broeker, Gerd; Speranza, Giovanna; Buckel, Wolfgang; Cornforth, Sir John; Golding, Bernard T.
Helvetica Chimica Acta, 2000 , vol. 83, # 9 p. 2550 - 2561
反应条件
thiamine pyrophosphate; α-ketoglutarate dehydrogenase; magnesium chloride in water
T=30°C; 2 h; 0.05M KH2PO4 buffer (pH 7.5); Further byproducts given. Yields of byproduct given;
参考文献
Corbett, Michael D.; Corbett, Bernadette R.; Doerge, Daniel R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 345 - 350
反应条件
thiamine pyrophosphate; α-ketoglutarate dehydrogenase; magnesium chloride in water
T=30°C; 2 h; 0.05M KH2PO4 buffer (pH 7.5); Further byproducts given. Yields of byproduct given;
参考文献
Corbett, Michael D.; Corbett, Bernadette R.; Doerge, Daniel R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 345 - 350
