2,3,5,6-四氢螺[吲哚-3,4-吡喃]-2(1H)-酮合成路线 （共 5 条）
反应条件
copper(I) oxide; 1,2-diamino-benzene; sodium t-butanolate in tert-butyl alcohol T=100°C; 24 h; Sealed tube;
参考文献
Jhan, Yu-Huei; Kang, Ting-Wei; Hsieh, Jen-Chieh
Tetrahedron Letters, 2013 , vol. 54, # 9 p. 1155 - 1159
反应条件
copper(l) iodide; N-acetyl-glycine; potassium iodide; sodium hydroxide in tert-butyl alcohol T=100°C; 24 h;
参考文献
Hsieh, Jen-Chieh; Cheng, An-Yi; Fu, Jun-Hao; Kang, Ting-Wei
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 31 p. 6404 - 6409
反应条件
1: 1,3-dihydro-indol-2-one With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexanes T=-78 - -70°C; 1 h; 2: 1,5-diiodo-3-oxa-pentane in tetrahydrofuran; hexanes T=-78 - 20°C; 48 h;
参考文献
MERCK and CO., INC.
Patent: WO2006/31610 A2, 2006 ;
Location in patent: Page/Page column 69 ;
WO 2006/031610 A2
反应条件
1: 1,3-dihydro-indol-2-one With lithium hexamethyldisilazane T=-78°C; 1 h; 2: bis-2-bromoethyl ether T=-50 - 25°C; 18 h; Reagent/catalystSolvent;
参考文献
JANSSEN RandD IRELAND; TAHRI, Abdellah; VENDEVILLE, Sandrine Marie Helene; JONCKERS, Tim Hugo Maria; RABOISSON, Pierre Jean-Marie Bernard; HU, Lili; DEMIN, Samuël Dominique; COOYMANS, Ludwig Paul
Patent: WO2014/60411 A1, 2014 ;
Location in patent: Page/Page column 36 ;
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 °C / Inert atmosphere 2: copper(l) iodide; N-acetyl-glycine; potassium iodide; sodium hydroxide / tert-butyl alcohol / 24 h / 100 °C View Scheme
参考文献
Hsieh, Jen-Chieh; Cheng, An-Yi; Fu, Jun-Hao; Kang, Ting-Wei
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 31 p. 6404 - 6409
